類風濕關節(jié)炎（rheumatoid arthritis，RA）是一種自身免疫性疾病，其主要病癥為小關節(jié)慢性滑膜炎癥的持續(xù)反復發(fā)作，致殘率較高。RA的治療一直是個難點，RA動物模型的研究也是關注的重點，有效的動物模型為RA發(fā)病機制研究和藥物篩選做出了不可替代的貢獻。然而由于物種的差異性，尚沒有一種模型可以完全模擬人類RA的發(fā)病過程和特點。為此對近年來RA嚙齒類實驗動物模型的研究近況進行了綜述。根據(jù)造模方式的不同分為誘導型、轉基因型和自發(fā)型，并進一步對模型獲得、病理生理過程特點、發(fā)病機制這幾個方面進行闡述，為RA研究中合理選擇實驗模型提供參考。

Rheumatoid arthritis (RA) is a devastating chronic inflammatory disorder which is characterized by autoimmune reactivity and persistent active inflammation with concurrent tissue destruction, and its rate of disability is high. Effective models serve as a valuable tool to investigate the pathogenesis and therapy of RA. There is no model to perfectly duplicate the condition of human RA for the genetic gap between human and rodent. This review gives a broad introduction of the current stage of RA rodent animal models which could be classified into three categories: induced, transgenic, and spontaneous models. The characterization of each model focuses on induction ways, features, and pathogenesis, which is useful for the selection of appropriate model for RA research.