目的 探討參黃膠囊對(duì)環(huán)磷酰胺致免疫抑制模型小鼠免疫功能的作用。方法 分別用環(huán)磷酰胺和限食法結(jié)合環(huán)磷酰胺兩種方法建立小鼠免疫抑制模型，分別給予0.26、0.53、1.06 g/kg參黃膠囊，觀察其對(duì)小鼠外周血T淋巴細(xì)胞率、胸腺指數(shù)、脾臟指數(shù)、白細(xì)胞數(shù)、巨噬細(xì)胞吞噬指數(shù)、血清溶血素含量（半數(shù)溶血值）的影響。結(jié)果 應(yīng)用環(huán)磷酰胺后,免疫抑制模型小鼠外周血T淋巴細(xì)胞率、胸腺指數(shù)、脾臟指數(shù)、白細(xì)胞數(shù)、巨噬細(xì)胞吞噬指數(shù)、血清溶血素含量均顯著降低。0.26、0.53、1.06 g/kg參黃膠囊均可明顯提高用限食法結(jié)合環(huán)磷酰胺致免疫低下（氣虛模型）小鼠外周血T淋巴細(xì)胞率、胸腺指數(shù)和脾臟指數(shù)和環(huán)磷酰胺致免疫低下小鼠體內(nèi)白細(xì)胞數(shù)和巨噬細(xì)胞吞噬指數(shù)；0.53、1.06 g/kg參黃膠囊可明顯促使溶血素生成增加。結(jié)論 參黃膠囊可明顯改善環(huán)磷酰胺致免疫低下小鼠的免疫功能，具有扶正固本、增強(qiáng)機(jī)體特異性免疫和非特異性免疫功能作用。

Objective To explore the effects of Shenhuang Capsule on immunofunction of cyclophosphamide (CY)- immunodepressed mice. Methods The immunosuppressive mouse models were established respectively by CY and CY combined with food restriction. After ig administration of Shenhuang Capsule (0.26, 0.53, and 1.06 g/kg), the effects of Shenhuang Capsule on T lymphocyte percentage in peripheral blood, thymus index, spleen index, leucocyte count, macrophage engulfing index, and serum haemolysin content (HC50) in mice were observed. Results There were significant reductions in T lymphocyte percentage in peripheral blood, thymus index, spleen index, leucocyte count, macrophage engulfing index, and HC50 in immunodepressive mice model induced by CY. Shenhuang Capsule (0.26, 0.53, and 1.06 g/kg) could obviously improve T lymphocyte percentage in peripheral blood, thymus index, and spleen index in immunosuppressive (Qi-asthenia model) mice treated by CY combined with food restriction, and elevate the leucocytes and macrophage engulfing index in CY-immunodepressed mice. Shenhuang Capsule (0.53 and 1.06 g/kg) could significantly promote haemolysin formation in CY-immunodepressed mice. Conclusion Shenhuang Capsule could significantly improve the immunofunction of CY-immunodepressed mice and have the effects on fostering resistance to disease and enhancing the body’s specific and nonspecific immunofunction.