目的 研究利克飛龍的抗炎作用。方法 通過ig給藥，觀察利克飛龍對大小鼠的抗炎活性以及炎性因子水平。結(jié)果 ig利克飛龍（60 mg/kg）對小鼠耳腫脹及角叉菜膠引起大鼠足趾腫脹抑制作用與甲潑尼龍（60 mg/kg）相當(dāng)，利克飛龍給藥一周對小鼠體質(zhì)量正常生長沒有影響，利克飛龍對炎性因子前列腺素E2（PGE2）含量降低作用與塞來昔布相當(dāng)。結(jié)論 利克飛龍具有高效的抗炎作用，其抗炎作用與甲潑尼龍相當(dāng)，其降低PGE2作用與塞來昔布相當(dāng)，且利克飛龍為COX/5-LOX雙靶標(biāo)抑制劑，理論上安全性更高，患者可長期服用，有望成為臨床上非甾體抗炎藥中的首選藥物之一。

Objective To study the anti-inflammatory effect of licofelone. Methods By ig administration, anti-inflammatory activity and inflammatory factor levels of licofelone were observed. Results The inhibition of licofelone (60 mg/kg) on ear swelling of mice and carrageenan-induced paw edema of rats were similar to those of methylprednisolone (60 mg/kg). Licofelone treatment for one week did not affect the normal growth of the body weight of mice. The decreasing of inflammatory factor PGE2 by licofelone was similar to that of celecoxib. Conclusion Licofelone has high anti-inflammatory effect, which is equivalent to that of methylprednisolone, and its anti-PGE2 effect is equivalent to that of celecoxib. Licofelone is an inhibitor for COX/5-LOX dual target, theoretically more secure, and could be long-term used in patients. It is expected to become one of the preferred drugs of non-steroidal anti-inflammatory drugs in clinic.