目的 觀(guān)察雷貝拉唑預(yù)防支氣管哮喘發(fā)作期糖皮質(zhì)激素治療誘發(fā)消化道潰瘍的療效。方法 支氣管哮喘急性發(fā)作期患者60例，隨機(jī)分為治療組（30例）和對(duì)照組（30例），對(duì)照組患者監(jiān)測(cè)生命體征，吸氧，維持電解質(zhì)酸堿平衡，同時(shí)給予注射用琥珀酸氫化可的松100 mg加入5%葡萄糖100 mL中，靜脈滴注，2次/d；二羥丙茶堿0.25 g加入5%葡萄糖100 mL中，靜脈滴注，2次/d；鹽酸氨溴索葡萄糖注射液100 mL，靜脈滴注，2次/d；孢硫脒2 g加入生理鹽水100 mL，靜脈滴注，2次/d，以抗生素控制感染。治療組患者口服雷貝拉唑10 mg/d，1次/d，其他治療同對(duì)照組。兩組均治療兩周。治療結(jié)束后通過(guò)觀(guān)察患者臨床癥狀積分、大便潛血實(shí)驗(yàn)及胃鏡等指標(biāo)評(píng)價(jià)兩組并發(fā)消化道潰瘍的發(fā)生率及不良反應(yīng)。結(jié)果 治療組和對(duì)照組并發(fā)消化道潰瘍的發(fā)生率分別為30%、60%，兩組比較有統(tǒng)計(jì)學(xué)差異（P＜0.05）。結(jié)論 雷貝拉唑能夠大大降低支氣管哮喘急性發(fā)作期糖皮質(zhì)激素誘發(fā)消化道潰瘍的發(fā)生率。

Objective To observe the curative effect of Rabeprazole on preventing the digestive tract ulcer induced by acute exacerbation of bronchial asthma treated with glucocorticoid. Methods The patients with acute exacerbation of bronchial asthma (60 cases) were randomly divided into treatment (30 cases) and control (30 cases) groups. The patients in the control group were given with oxygen, maintained the electrolyte acid-base balance, and the vital signs were monitored. The patients were iv administered with succinate cortisone (100 mg added into 100 mL 5% glucose) and iv administered with diprophylline (0.25 g added into 100 mL 5% glucose) twice daily. The patients in the control group were iv administered with 100 mL ambroxol glucose injection and spore cefathiamidine (2 g added into 100 mL physiological saline), twice daily, with antibiotics to control infection. The patients in the treatment group were po administered with Rabeprazole (10 mg/d), once daily, and other treatments were the same as the control group. Two groups were treated for two weeks. The incidence of the digestive tract ulcer and its adverse reactions were evaluated by observing the clinical symptom score, fecal occult blood test, endoscopy, and other indicators after treatment. Results The incidence of the digestive tract ulcer in the treatment and control groups was 30% and 60%, respectively with significant differences (P < 0.05). Conclusion Rabeprazole could greatly reduce the incidence of the digestive tract ulcer induced by acute exacerbation of bronchial asthma treated with glucocorticoid.