目的 分析天津市第三中心醫(yī)院開展抗菌藥物臨床應(yīng)用專項管理前后各科室的抗菌藥物管理指標(biāo)，為抗菌藥物合理應(yīng)用提供依據(jù)。方法 根據(jù)天津市第三中心醫(yī)院信息系統(tǒng)（HIS）數(shù)據(jù)，回顧性收集管理前后2011年1～7月份與2012年1～7月份的抗菌藥物相關(guān)數(shù)據(jù)，根據(jù)世界衛(wèi)生組織定義的限定日劑量（defined daily dose，DDD），計算抗菌藥物使用強度（antibacterial use density，AUD）。將相關(guān)數(shù)據(jù)運用Excel 2003軟件電子表格進(jìn)行分類、匯總及篩選，評價相關(guān)指標(biāo)對AUD的影響，分析降低AUD的措施是否有效。結(jié)果 管理后天津市第三中心醫(yī)院抗菌藥物使用率及AUD、Ⅰ類切口手術(shù)預(yù)防用抗菌藥物使用率均明顯下降，病原學(xué)送檢率明顯升高，2012年所有指標(biāo)均達(dá)到衛(wèi)生部抗菌藥物應(yīng)用指標(biāo)要求。結(jié)論 天津市第三中心醫(yī)院抗菌藥物專項管理措施很有成效。

Objective To provide the evidence for the rational use of antibacterials in clinic through analysis on the controlling indicators of all divisions before and after special clinical antibacterial managements in Tianjin Third Center Hospital. Methods According to Tianjin Third Center Hospital information system (HIS), the data of antibacterials used from January to August in 2011 and 2012 before and after management were collected and analyzed by Excel 2003 with retrospective study. According to World Health Organization defined daily dose (DDD), we calculated the antibacterial use density (AUD). We evaluated the impact of relevant indicators for AUD, and analyzed the effectiveness of measures to reduce AUD. Results The antibacterial usage, AUD, and the preventive use of antibiotics of type I incision in Tianjin Third Center Hospital after management have decreased. The rate of pathogenic detection had significantly increased. All indicators in 2012 had reached the grade of Ministry of Health in our country. Conclusion The special managements in Tianjin Third Center Hospital are efficacy.