在惡性腫瘤、膿毒血癥、糖尿病甚至長(zhǎng)期太空飛行等狀態(tài)下常伴隨著骨骼肌萎縮的現(xiàn)象。骨骼肌萎縮是肌蛋白合成下降和（或）分解代謝加速的結(jié)果。骨骼肌萎縮的程度與患者的康復(fù)、生活能力和生活質(zhì)量息息相關(guān)，防治并逆轉(zhuǎn)骨骼肌的萎縮對(duì)上述疾病的治療具有重要意義?，F(xiàn)代醫(yī)學(xué)對(duì)骨骼肌萎縮的分子生物學(xué)機(jī)制進(jìn)行了大量研究，對(duì)近年骨骼肌萎縮相關(guān)信號(hào)通路及藥物對(duì)其防治作用做一簡(jiǎn)要綜述，以期對(duì)骨骼肌萎縮相關(guān)疾病的研究與治療提供參考。

Skeletal muscle atrophy often accompanies with tumors, sepsis, diabetes, and even long-term space flight. Skeletal muscle atrophy lies in the decrease of muscle protein synthesis and/or catabolism acceleration. Since the degree of skeletal muscle atrophy is closely related with the rehabilitation, live abilities, and living quality of patients, the prevention and reversal of skeletal muscle atrophy are of great significance. Modern researchers have undertaken the abundant researches on the molecular biology mechanism of skeletal muscle atrophy. Recent investigations on the preventive effect of the medicine on the signaling pathway of skeletal muscle atrophy are briefly summarized, in order to offer the guidance for the research and treatment of the skeletal muscle atrophy related disease.