摘 要：目的 對圓滑番荔枝種子氯仿部分的化學成分進行研究。方法 運用正反相硅膠、Sephadex LH-20凝膠及制備高效液相等色譜技術進行分離純化，并根據(jù)理化性質(zhì)和波譜數(shù)據(jù)鑒定化合物的結構。結果 分離得到13個化合物，分別鑒定為去乙酰紫玉盤素（1）、去乙酰異紫玉盤素（2）、泡泡樹新素（3）、泡番荔枝辛（4）、毛曲番荔枝素（5）、4-desoxycherimolin-2（6）、atemotetrolin（7）、毛葉番荔枝素-2（8）、刺果番荔枝素B（9）、glabrin A（10）、鄰苯二甲酸二丁酯（11）、番荔枝五醇C（12）、蔗糖（13）。結論 其中化合物7和12為首次從該植物中分離得到，化合物11和13為首次從該屬植物中分離得到。

Abstract: Objective To study the chemical constituents in chloroform fraction from the seeds of Annona glabra. Methods The compounds were isolated by silica gel, reverse phase C18 silica gel, Sephadex LH-20 column chromatographies and pre-HPLC. Their structures were identified on the basis of physicochemical properties and spectroscopic data. Results Thirteen compounds were isolated and identified as desacetyluvaricin (1), 4-deoxyasimicin (2), asimicin (3), bullatacin (4), motrilin (5), 4-desoxycherimolin-2 (6), atemotetrolin (7), cherimolin-2 (8), muricatetrocin B (9), glabrin A (10), dibutyl phthalate (11), annopentocin C (12), and sucrose (13). Conclusion Compounds 7 and 12 are isolated from this plant for the first time, and compounds 11 and 13 are isolated from this genus for the first time.

科技部“重大新藥創(chuàng)制”科技重大專項（2009ZX09103-390）