目的 優(yōu)選夏黃顆粒處方藥材的最佳提取工藝。方法 采用高效液相色譜法，建立夏黃顆粒的全息圖譜以及5種蒽醌類成分的測(cè)定方法，并對(duì)水回流提取、水提醇沉、醇回流提取、水煎煮、醇提結(jié)合水提、水提醇沉結(jié)合醇滲漉6種提取工藝進(jìn)行比較。以總蒽醌轉(zhuǎn)移率、結(jié)合蒽醌質(zhì)量為指標(biāo)并結(jié)合全方全息譜優(yōu)選出最佳提取方法。結(jié)果 夏黃顆粒的6種提取工藝中，醇回流提取總蒽醌轉(zhuǎn)移率最高、結(jié)合蒽醌質(zhì)量也最高，全息譜中各峰相對(duì)面積也較大。結(jié)論 醇回流提取工藝為夏黃顆粒處方藥材的最佳工藝。

Objective To optimize the extraction technology for medicinal materials in Xiahuang Granule prescription. Methods HPLC method was used to establish the holographic spectrum as well as determination of five kinds of anthraquinones in Xiahuang Granule. Six extracting processes, such as water reflux extraction, water extraction and alcohol precipitation, alcohol reflux extraction, boiling water extraction, alcohol extract combined with water extraction, and alcohol precipitation combined with alcohol leakage process were compared to optimize extraction process. Results Ethanol extracting process had the highest yield of five anthraquinones and the highest weights of combined anthraquinones in six extracting process of Xiahuang Granule with the biggest relative area of the holographic spectrum peaks. Conclusion The optimal process is the ethanol reflux extracting process for medicinal materials in Xiahuang Granule prescription.

國家“十二五”科技支撐計(jì)劃項(xiàng)目（2011BA107B01）；天津市科技計(jì)劃項(xiàng)目（13ZCZDSY00200）