目的 觀察降糖保腎寧對早期糖尿病腎病的臨床療效及早期干預的應用價值，為該病的治療方法提供理論依據。方法 將符合納入標準的68例受試者隨機分為治療組（34例）和對照組（34例）。兩組患者均給予基礎治療，對照組口服氯沙坦鉀片，50 mg/次，1次/d。治療組口服降糖保腎寧，200 mL/次，早晚各1次。兩組均治療4周，隨訪6個月。治療前后分別觀察兩組患者的糖化血紅蛋白、空腹血糖、餐后2 h血糖、尿白蛋白排泄率、血壓、血脂全項、腎功能、臨床癥狀積分、安全性等指標的變化，判斷臨床療效。隨訪6個月，探討早期干預對早期糖尿病腎病的臨床應用價值。結果 降糖保腎寧不僅能改善患者的癥狀體征，而且對患者的糖脂代謝和腎小球濾過率、腎血流、尿白蛋白水平都有很好的調節(jié)作用，與對照組比較差異有統(tǒng)計學意義。通過6個月的隨訪發(fā)現治療組患者的病情都得到較好控制。結論 降糖保腎寧對糖尿病腎病具有較好的臨床療效，且長期療效較好。降糖保腎寧早期干預對于早期糖尿病腎病的治療具有臨床開發(fā)價值。

Objective To observe the effect of Jiangtang Baoshenning in early diabetic nephropathy and the application value of early intervention, and to provide the theoretical foundation for the treatment in early diabetic nephropathy. Methods Patients who accorded the inclusive criteria (68 cases) were randomly divided into treatment (34 cases) and control (34 cases) groups. Two groups of patients were given the basic treatment. The patients in the control group were po administered with Losartan Potassium Tablets, 50 mg, once daily. The patients in the treatment group were po administered with Jiangtang Baoshenning, 200 mL/time, twice daily in the morning and night. Two groups were treated for 4 weeks, and followed up for 6 months. The changes of glycosylated hemoglobin, fasting blood sugar, 2 h postprandial blood glucose, urine albumin excretion rate, blood pressure, blood lipid, renal function, clinical symptoms integral, and security were observed to estimate the curative effect. The patients were followed up for 6 months to explore the clinical value of early intervention on early diabetic nephropathy. Results Jiangtang Baoshenning could not only improve the symptoms and signs of patients, but also had good adjustment function on the glucolipid metabolism, glomerular filtration rate, renal blood flow, and urine albumin levels of patients, with significant difference compared with the control group. Through 6 months of follow-up, states of illness in treatment group was better than that in the control group. Conclusion Jiangtang Baoshenning has an accurate curative effect on diabetic nephropathy, with better long-term curative effect. Early intervention of Jiangtangbaoshenning has development value for the treatment of early diabetic nephropathy.