眾所周知，分娩是一個痛苦的過程。哌替啶為人工合成的阿片受體激動藥，便宜易得，是最常用于產(chǎn)科鎮(zhèn)痛的阿片類藥物，有較好的鎮(zhèn)痛效果，但是，由于其可能造成產(chǎn)婦惡心、嘔吐、煩躁不安、呼吸抑制等副作用以及其對新生兒的影響，哌替啶對分娩疼痛的緩解效果存在爭議。通過檢索各國文獻(xiàn)，對哌替啶在分娩鎮(zhèn)痛中的作用機(jī)制、臨床研究、系統(tǒng)評價、不良反應(yīng)以及爭議的研究進(jìn)展進(jìn)行綜述。

Childbirth is a painful process. Pethidine is a synthetic opioid receptor agonists, cheap and easy to get, and is the most commonly used opioids for obstetric analgesia. Pethidine has good performance in analgesic effect, however, because it may cause maternal nausea, vomiting, irritability, respiratory depression, and other side effects as well as its effects on the newborn, it is controversial about the labor pain relief effect of pethidine. By searching national literature, mechanism of action, clinical research, system evaluation, adverse reaction, and controversy of pethidine for labor analgesia are reported currently in this paper.