目的 考察4種不同型號直壓甘露醇M200、M100、C、D的粉體學(xué)性能。方法 測定4種甘露醇的休止角、模型藥物的粒度、粒度分布、比表面積等指標(biāo)以及電鏡掃描圖。選擇模型藥物考察甘露醇的容納性，評價其在粉末直接壓片工藝中的應(yīng)用。結(jié)果 4種型號甘露醇均具有良好的流動性，且對模型藥物有很好的容納性。結(jié)論 甘露醇是良好的直壓工藝的填充劑，不同型號的甘露醇對模型藥物的容納性有一定差異。

Objective To Investigate the powder properties of four different types of direct pressure mannitol (mannitol M200, M100, C, and D). Methods The angle of repose of four mannitols, particle sizes of model drugs, the distribution of particle size, and specific surface area were determined, as well as the electron microscope scan was studied. The containment of the mannitols by choosing a model drug was examined to evaluate the applications in the powder direct pressure process. Results All of the four models of mannitols had the good mobility and good containment on model drugs. Conclusions Mannitol is a good filler in the direct pressure process and different types of mannitols have different containment in the model drug.