目的 觀察單硝酸異山梨酯片聯(lián)合定痛救心膠囊對(duì)冠脈介入術(shù)（PCI）后再發(fā)穩(wěn)定型心絞痛的臨床療效和安全性。方法 將48例PCI后再發(fā)穩(wěn)定型心絞痛患者隨機(jī)分為治療組（24例）和對(duì)照組（24例）。對(duì)照組口服單硝酸異山梨酯片20 mg/次，3次/d；治療組口服定痛救心膠囊6粒/次，3次/d，單硝酸異山梨酯片的用法和用量同對(duì)照組，兩組患者均持續(xù)治療8周。治療結(jié)束后，觀察兩組患者臨床療效、心電圖變化、中醫(yī)證候療效。結(jié)果 治療后治療組臨床療效、心電圖變化、中醫(yī)證候療效與對(duì)照組比較差異均有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 單硝酸異山梨酯片聯(lián)合定痛救心膠囊能有效地改善PCI術(shù)后再發(fā)穩(wěn)定型心絞痛患者的療效，且無(wú)不良反應(yīng)，值得臨床推廣。

Objective To investigate the clinical efficacy and safety of Isosorbide Mononitrate Tablets combined with Dingtong Jiuxin Capsule used for the treatment of stable angina pectoris reappeard after percutaneous coronary intervention. Methods The 48 cases of stable angina pectoris reappeard after percutaneous coronary intervention were randomly divided into treatment (24 cases) and control (24 cases) groups. The patients in the control group were po administered with Isosorbide Mononitrate Tablets 20 mg/time, three times daily. The patients in the treatment group were po administered with Dingtong Jiuxin Capsule 6 pieces/time, three times daily, at the same time, Isosorbide Mononitrate Table at the usage and dosage was used as same in the control group. Two groups were treated for eight weeks. After the treatment, the changes of clinical curative effect, electrocardiogram, and traditional Chinese medicine (TCM) syndrome curative effect were observed in the two groups. Results The differences of clinical curative effect, electrocardiogram, and TCM syndrome curative effect between the two groups were statistically significant (P < 0.05). Conclusion Isosorbide Mononitrate Tablets combined with Dingtong Jiuxin Capsule can effectively improve the curative effect of stable angina pectoris reappeard after percutaneous coronary intervention with no adverse reactions, which is worthy of the clinical promotion.

天津市衛(wèi)生局科研基金資助課題（200019）