目的 探討益生菌輔助治療對(duì)嬰幼兒濕疹的臨床療效和安全性。方法 抽選眉山市人民醫(yī)院收治的100例嬰幼兒濕疹患者，隨機(jī)分為對(duì)照組（50例）和治療組（50例），對(duì)照組采用常規(guī)治療。治療組在對(duì)照組的基礎(chǔ)上加用紐曼斯益生菌輔助治療，1歲以內(nèi)患兒半粒/d，1歲以上1～2粒/d，在兩餐中間，餐前空腹服用，兩組均治療4周后評(píng)價(jià)療效。結(jié)果 兩組患者治療后，治療組和對(duì)照組的總有效率分別為92.0%、78.0%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療組治療后2、3個(gè)月濕疹的復(fù)發(fā)率分別為6%、8%，明顯低于對(duì)照組的18%、28%，兩組比較差異均有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療4周后治療組患者IL-10、IFN-α等細(xì)胞因子水平及Thl/Th2免疫平衡指標(biāo)改善均明顯優(yōu)于對(duì)照組，兩組比較差異均有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 在基礎(chǔ)治療上補(bǔ)充一定劑量的紐曼斯益生菌，可刺激患兒的腸道免疫機(jī)能，調(diào)節(jié)宿主免疫活性，增強(qiáng)其免疫力，減少患兒濕疹復(fù)發(fā)率，值得臨床推廣。

Objective To investigate the clinical efficacy and safety of probiotics in adjuvant treatment of infantile eczema. Methods One hundred cases with infantile eczema in Meishan City People's Hospital were chosen, and they were randomly divided into control (50 cases) and treatment (50 cases) groups. The patients in the control group were treated with conventional therapy. The patients in the treatment group were treated with Newmans probiotics on the basis of the control group, the children within one-year old were given half grain/d, over one-year 1－2 grains/d, between the two meals, taken by empty stomach before a meal. The efficacy of two groups was evaluated after 4 weeks. Results After the treatment, the total effective rates in the treatment group and the control group were 92.0% and 78.0%, and there were significant differences between the two groups (P<0.05). After 2- 3 months treatment, eczema recurrence rates in the treatment group were 6% and 8%, significantly lower than those in the control group 18%and 28%, and there were statistically significant (P<0.05). After 4 weeks of the treatment, the levels of cytokines and Thl/Th2 in the treatment group was significantly better improved than those in the control group. The difference between the two groups were statistically significant (P<0.05). Conclusion Newmans probiotics on the basis of basic treatment can stimulate the intestinal immune function in children and regulate the immune activity of the host, which could enhance the immunity and reduce the rate of recurrence in the children with eczema. The therapy is worth the clinical promotion.

國(guó)家自然科學(xué)基金資助項(xiàng)目（30901292）