目的 觀察重組人干擾素α-2b注射液霧化吸入治療兒童手足口病的臨床療效。方法 選取2013年5—9月來首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院兒科就診的患兒164例，隨機(jī)分為治療組（84例）和對照組（80例）。對照組給予對癥基礎(chǔ)治療。治療組在對照組基礎(chǔ)上再加用重組人干擾素α-2b注射液300萬單位，生理鹽水2 mL稀釋，空氣壓縮霧化吸入，體積流量4 L/min，2次/d，觀察期為7 d。3 d為1個(gè)療程，觀察3、6 d內(nèi)兩組體溫、進(jìn)食及皰疹改善情況。結(jié)果 治療組的效果明顯優(yōu)于對照組，治療組的總有效率（98.8%）高于對照組（91.3%），差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05）；同時(shí)治療組3、6 d內(nèi)體溫和皰疹情況皆優(yōu)于對照組，差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05）；治療組3、6 d進(jìn)食情況差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 重組人干擾素α-2b注射液霧化吸入對于促進(jìn)手足口病患兒體溫恢復(fù)及皰疹愈合方面的臨床療效滿意，且安全性好，值得臨床進(jìn)一步研究推廣。

Objective To observe the clinical efficacy of Recombinant Human Interferon α-2b Injection by aerosol inhalation in treatment of hand-foot-mouth disease of children. Methods The children (164 cases) diagnosed with hand-foot-mouth disease in Beijing YouAn Hospital, Capital Medical University from May to September 2013 were randomly divided into treatment (84 cases) and control (80 cases) groups. The children in the control group were administered with symptomatic treatment. On the basis of the control group, the children in the treatment group were administered with Recombinant Human Interferon α-2b Injection 3 million U, twice daily by compressed air and aerosol inhalation, which was diluted by physiological saline 2 mL. The flow rate was 4 L/min. Both the children in the two groups were observed for 7 d. A treatment period was 3 d. The improvement of the body temperature, feeding, and herpes of children in the two groups was obtained in 3 and 6 d during the treatment. Results The effect in the treatment group was better than that in the control group. The total efficacies in the treatment and control groups were 98.8% and 91.3%, respectively, with the significant difference between the two groups (P < 0.05). The effect of body temperature and herpes of the children in the treatment group in 3 and 6 d during the treatment was better than that of the children in the control group, with the significant difference between the two groups (P < 0.05). The difference of feeding in the two groups in 3 and 6 d was not statistically significant. Conclusion Recombinant Human Interferon α-2b Injection by aerosol inhalation in the treatment of hand-foot-mouth disease of children can promote the temperature recovery and herpes healing of the children with hand-foot-mouth disease, and the therapeutic effect is reliable and safety in clinic is satisfied. So it is worth further researching and widely using in clinic.