目的 優(yōu)化尼美舒利乳膏劑的處方。方法 選用L₉（3⁴）正交設(shè)計(jì)對(duì)尼美舒利乳膏的處方進(jìn)行優(yōu)化篩選，選氮酮、丙二醇和平平加O20為3個(gè)影響因素，每個(gè)因素各取3個(gè)水平，用藥物透皮擴(kuò)散試驗(yàn)儀，以離體小鼠腹部皮膚為屏障，pH 7.4磷酸鹽緩沖液為接受介質(zhì)，（37±1）℃恒溫水浴，轉(zhuǎn)速500 r/min，測(cè)定不同處方的滲透速率。結(jié)果 氮酮是影響透皮吸收速率的主要因素，其次是平平加O20。最佳工藝條件是氮酮3%、丙二醇15%、平平加O20 1%。從累積滲透量–時(shí)間曲線方程可以看出，透皮吸收符合零級(jí)方程。結(jié)論 尼美舒利乳膏劑的處方合理，制備工藝可行。

Objective To optimize the prescription of Nimesulide Cream. Methods L₉(3⁴) orthogonal design was used to optimize the prescription of Nimesulide Cream. Azone, propylene glycol, and peregal O20 were selected as three factors, and each factor formed three levels. Permeation rates were determined with Franz diffusion device in isolated mouse abdominal skin as a barrier. Phosphate buffer (pH 7.4) was used as acceptable medium in (37 ± 1) ℃ water bath with speed of 500 r/min. Results Azone was the main factor affecting the rate of percutaneous absorption, and the following was peregal O20. The optimal conditions were determined by the experimental data, such as 3% azone, 15% propylene glycol, and 1% peregal O20. It could be conclude from the cumulative permeation quantity - time curve that transdermal absorption accorded with Zero order equation. Conclusion The prescription of Nimesulide Cream is reasonable, and the preparation technology is feasible.