9(34)正交設(shè)計對尼美舒利乳膏的處方進行優(yōu)化篩選,選氮酮、丙二醇和平平加O20為3個影響因素,每個因素各取3個水平,用藥物透皮擴散試驗儀,以離體小鼠腹部皮膚為屏障,pH 7.4磷酸鹽緩沖液為接受介質(zhì),(37±1)℃恒溫水浴,轉(zhuǎn)速500 r/min,測定不同處方的滲透速率。結(jié)果 氮酮是影響透皮吸收速率的主要因素,其次是平平加O20。最佳工藝條件是氮酮3%、丙二醇15%、平平加O20 1%。從累積滲透量–時間曲線方程可以看出,透皮吸收符合零級方程。結(jié)論 尼美舒利乳膏劑的處方合理,制備工藝可行。;Objective To optimize the prescription of Nimesulide Cream. Methods L9(34) orthogonal design was used to optimize the prescription of Nimesulide Cream. Azone, propylene glycol, and peregal O20 were selected as three factors, and each factor formed three levels. Permeation rates were determined with Franz diffusion device in isolated mouse abdominal skin as a barrier. Phosphate buffer (pH 7.4) was used as acceptable medium in (37 ± 1) ℃ water bath with speed of 500 r/min. Results Azone was the main factor affecting the rate of percutaneous absorption, and the following was peregal O20. The optimal conditions were determined by the experimental data, such as 3% azone, 15% propylene glycol, and 1% peregal O20. It could be conclude from the cumulative permeation quantity - time curve that transdermal absorption accorded with Zero order equation. Conclusion The prescription of Nimesulide Cream is reasonable, and the preparation technology is feasible."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁 > 過刊瀏覽>2014年第29卷第5期 >2014,29(5):481-484. DOI:10.7501/j.issn.1674-5515.2014.05.007
上一篇 | 下一篇

正交試驗優(yōu)化尼美舒利乳膏的處方研究

Optimization of prescription of Nimesulide Cream by orthogonal test

發(fā)布日期:2014-06-12