18色譜柱(200 mm×4.6 mm,5 μm);流動(dòng)相:甲醇–水(90:10);檢測(cè)波長(zhǎng):288 nm;柱溫:25 ℃;體積流量:1.0 mL/min;進(jìn)樣量10 μL。結(jié)果 非諾貝特在2.0~12.0 μg/mL與其峰面積呈良好的線(xiàn)性關(guān)系(r=0.999 9);檢測(cè)限和定量限分別為10、30 ng/mL;平均回收率為99.86%,RSD值為0.72%(n=9)。結(jié)論 該方法準(zhǔn)確、簡(jiǎn)便,可用于非諾貝特緩釋片中非諾貝特的質(zhì)量控制。;Objective To establish an HPLC method for determining fenofibrate in Fenofibrate Sustained-release Tablets. Methods HPLC was carried out on a Dikma C18 column (200 mm × 4.6 mm, 5 μm) with methanol - water (90:10) as mobile phase. The detection wavelength was set at 288 nm. The injection volume was 20 μL at the flow rate of 1.0 mL/min. The temperature of column was set at 25 ℃. Results There were good linear relationship of fenofibrate in the range of 2 — 12 μg/mL (r = 0.999 9). The limits of detection and quantitation were 10 and 30 ng/mL, respectively. The average recoveries was 99.86% with RSD value of 0.72% (n = 9). Conclusion The method is accurate and simple for quality control of fenofibrate in Fenofibrate Sustained-release Tablets."/>