目的 觀察芪桂痛風(fēng)片對(duì)大鼠關(guān)節(jié)炎模型、小鼠熱板和醋酸致小鼠扭體模型的影響。方法 給予芪桂痛風(fēng)片5 d后，觀察芪桂痛風(fēng)片對(duì)尿酸鈉致大鼠關(guān)節(jié)炎模型痛閾改變的影響；采用小鼠熱板模型，觀察小鼠給予芪桂痛風(fēng)片后舔足潛伏期的變化；小鼠ip 0.7%醋酸，觀察給予芪桂痛風(fēng)片后對(duì)小鼠扭體反應(yīng)次數(shù)和扭體潛伏期的影響。結(jié)果 大鼠關(guān)節(jié)炎模型造模1 h后，芪桂痛風(fēng)片8.10 g/kg劑量組大鼠痛閾降低值和降低率與模型組比較差異具有顯著性（P<0.01）；造模3、5 h后，芪桂痛風(fēng)片4.05、8.10 g/kg劑量組大鼠痛閾降低值和降低率較模型組低，且差異均具有顯著性（P<0.05、0.01）。末次給藥60、90、120 min后，芪桂痛風(fēng)片各劑量（11.70、5.85、2.93 g/kg）組小鼠舔足潛伏期均比模型組延長(zhǎng)。芪桂痛風(fēng)片各劑量（11.70、5.85、2.93 g/kg）組小鼠扭體次數(shù)和扭體率均低于模型組，小鼠扭體潛伏期高于模型組。結(jié)論 芪桂痛風(fēng)片能夠減輕尿酸鈉注射引起的大鼠關(guān)節(jié)痛閾降低，并減輕小鼠熱板和醋酸引起的疼痛，提示芪桂痛風(fēng)片具有抗實(shí)驗(yàn)性痛風(fēng)性關(guān)節(jié)炎作用。

Objective To investigate the effects of the Qigui Tongfeng Tablets on monosodium urate crystal-induced arthritis in rats and mice, as well as to observe the analgesic effects in mice. Methods Pain threshold changes of rats with arthritis model induced by intra-articular injection of monosodium urate crystal suspension inside the ankle joint were observed after administrated Qigui Tongfeng Tablets for 3 d. The latency of licking foot was measured after being administrated Qigui Tongfeng Tablets in hot-plate model mice. The writhing times and writhing latency of mice with pain model induced by ip 0.7% acetic acid were observed after administrated Qigui Tongfeng Tablets. Results There was significant difference (P<0.01) between the model group and 8.10 g/kg Qigui Tongfeng Tablets group in the value and rate of pain threshold changes after 1 h arthritis model being made, and there was also significant difference (P<0.05, 0.01) between the model group and 4.05, 8.10 g/kg Qigui Tongfeng Tablets groups after 3,5 h. The latency of licking foot of mice in Qigui Tongfeng Tablets (11.70, 5.85, 2.93 g/kg) groups was longer than that of mice in the model group after 60, 90, and 120 min since last administration. The writhing times and writhing rats of mice in Qigui Tongfeng Tablets (11.70, 5.85, 2.93 g/kg) groups were lower than those of mice in the model group, while writhing latency opposite. Conclusion Qigui Tongfeng Tablets have the effects of reducing pain threshold decrease of arthritis model of rats induced by intra-articular injection, relieving the mice pain induced by hot-plate and acetic acid. It suggests that Qigui Tongfeng Tablets could exert the effect in the treatment of acute gouty arthritis.

國家重大新藥創(chuàng)制項(xiàng)目（2013ZX09402203）