目的 觀察炔雌醇環(huán)丙孕酮片與散結(jié)鎮(zhèn)痛膠囊聯(lián)合治療子宮腺肌病的臨床療效。方法 選取2013年l-6月天津市靜海縣醫(yī)院收治的伴有不同程度痛經(jīng)的子宮腺肌病患者60例，隨機分為治療組和對照組，各30例。兩組均于月經(jīng)來潮第5天開始服用炔雌醇環(huán)丙孕酮片，1片/d，連續(xù)服用21 d，治療組于月經(jīng)第1天時加服散結(jié)鎮(zhèn)痛膠囊，1.6 g/次，3次/d，連續(xù)3～6個月。隨訪6個月，隨訪內(nèi)容包括痛經(jīng)情況、月經(jīng)量、子宮體積及CA12-5水平等。結(jié)果 對照組總有效率為86.67%，治療組為96.77%，兩組總有效率比較差異具有統(tǒng)計學意義（P<0.05）。治療6個月后，兩組患者痛經(jīng)情況、月經(jīng)量、子宮體積及CA12-5水平均較治療前明顯改善（P<0.05），但治療組改善情況均優(yōu)于對照組，差異具有統(tǒng)計學意義（P<0.05）。治療過程中未出現(xiàn)明顯不良反應。結(jié)論 炔雌醇環(huán)丙孕酮片聯(lián)合散結(jié)鎮(zhèn)痛膠囊治療子宮腺肌病具有較好的臨床療效。

Objective To observe the therapeutic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Sanjie Zhentong Capsules in the treatment of adenomyosis. Methods Patients (60 cases) with myopathy associated with different degrees of dysmenorrhea in adenomyosis, who came to Hospital of Jinghai County of Tianjin City for the treatment from January to June 2013, were randomly divided into treatment and control groups (30 cases in each group). Patients in the both groups took Ethinylestradiol and Cyproterone Acetate Tablets 1 tablet daily, for 21 d from day 5 of menstruation. On the basis of conventional therapy, the patients in the treatment group took Sanjie Zhentong Capsules 1.6 g once, three times daily, for 3-6 months on day 1 of menstruation. The patients were followed up for 6 months including dysmenorrhea, menstrual quantity, uterus volume, and CA12-5 level. Results The total effective rate for the patients in the control group was 86.67%, the treatment group was 96.77%, and the difference between the two groups was statistically significant (P< 0.05). After the treatment for 6 months, dysmenorrhea, menstrual quantity, uterus volume and CA12-5 level were significantly improved compared with the same group before the treatment (P< 0.05), and efficacy in the treatment group was significantly better than that in the control group (P< 0.05).There were not obvious adverse reactions during the treatment. Conclusion Ethinylestradiol and Cyproterone Acetate Tablets combined with Sanjie Zhentong Capsule in the treatment of adenomyosis have good clinical effect.