目的 評價寶雞市中心醫(yī)院臨床藥師干預(yù)骨科Ⅰ類切口手術(shù)預(yù)防性應(yīng)用抗菌藥物的效果。方法 選取寶雞市中心醫(yī)院骨科2011年9月-12月（干預(yù)前組）和2013年9月-12月（干預(yù)后組）出院的骨科Ⅰ類切口手術(shù)病歷，進行統(tǒng)計、分析。結(jié)果 通過臨床藥師干預(yù)，醫(yī)院骨科Ⅰ類切口手術(shù)抗菌藥物使用率顯著下降，用藥時機和療程合理性顯著提高，規(guī)范了抗菌藥物品種選擇，同時使患者的治療費用顯著降低。結(jié)論 通過臨床藥師的干預(yù)可顯著提高骨科Ⅰ類切口手術(shù)預(yù)防性抗菌藥物的合理應(yīng)用水平，同時降低患者的治療費用。

Objective To assess the effect of antibiotics used for the intervention on the surgical prevention of type I incision in Orthopedics Department of Baoji Central Hospital. Methods The discharged cases of patients undergoing type I incision orthopedic surgery in Baoji Central Hospital from September to December 2011 were selected as control group, and the same cases from September to December 2013 were selected as intervention group. The data conducted were statistically collected and analyzed. Results Through the intervention, the usage rate of antibiotics decreased significantly, while the rationality of the time and the course of using antibiotics improved. The variety choice of antibiotics was more regulated, and the cost of the treatment decreased. Conclusion Through the intervention of clinical pharmacist, the rationality of antibiotic usage for type I incision on surgical prevention in Orthopedics Department improves and the patient's cost used for the treatment decreases.

陜西省衛(wèi)生廳衛(wèi)生科研基金項目（2010H42）