目的 建立離子色譜法測定炎琥寧原料藥中碳酸鹽殘留的方法。方法 采用離子色譜法。色譜柱：Dionex IonPac AS18（250 mm×4 mm）；淋洗液：0.022 mol/L氫氧化鉀；體積流量：1.0 mL/min；進(jìn)樣體積：10 μL；柱溫：30 ℃；檢測器：電導(dǎo)檢測器；檢測池溫度：35 ℃；抑制器：Dionex ASRS 300（4 mm）。結(jié)果 CO₃^2-與Cl^-、NO₂^-、NO₃^-、SO₄^2-分離良好，CO₃^2-在10～120 μg/mL與峰面積呈良好的線性關(guān)系（r=0.999 0）；平均回收率為102.1%，RSD值為3.7%（n=9）。結(jié)論 該方法靈敏、準(zhǔn)確、簡便，專屬性好，可用于測定炎琥寧原料藥中碳酸鹽的殘留。

Objective To establish a method to determine the residual of carbonate in potassium sodium dehydroandroan drographolide succinate by ion chromatography. Ion chromatography was used. The separation was carried out on a Dionex IonPac AS18 column (250 mm × 4 mm) with 0.022 mol/L KOH as mobile phase. The injection volume was 10 μL at the flow rate of 1.0 mL/min. The temperature of column was set at 30 ℃. Conductivity detector with temperature of detector cell 35 ℃ was used. Dionex ASRS 300 (4 mm) was used as suppressor.Results There was good separation between CO₃^2- and Cl^-, NO₂^-, NO₃^-, and SO₄^2-. The standard curve was rectilinear in the range of 10 — 120 μg/mL (r=0.999 0). The average recovery was 102.1% with RSD value of 3.7% (n = 9). Conclusion This method is accurate, simple, and selective which could be used for the determination of the residual of carbonate in potassium sodium dehydroandroan drographolide succinate.