目的 建立GC法測定小兒氨酚烷胺顆粒中鹽酸金剛烷胺。方法 采用HP-5毛細(xì)管柱（30 m×0.32 mm×0.25 μm），F(xiàn)ID檢測器；氣化室溫度為220 ℃，檢測室溫度為300 ℃。采用程序升溫，初始溫度為70 ℃，以10 ℃/min升至140 ℃。載氣：氮氣，流速為4 mL/min；進(jìn)樣量為1 μL；分流比：1：50。采用內(nèi)標(biāo)法定量。結(jié)果 鹽酸金剛烷胺在0.1～0.7 mg/mL線性關(guān)系良好（r=0.999 6）。平均回收率為99.27%，RSD值為0.66%（n=9）。結(jié)論 本法簡便、準(zhǔn)確、重復(fù)性好，可用于小兒氨酚烷胺顆粒中鹽酸金剛烷胺的測定。

Objective To establish a method for the determination of amantadine hydrochloride in Pediatric Paracetamol and Amantadine Hydrochloride Granules. Methods The determination was carried out on HP-5 capillary chromatographic column (30 m × 0.32 mm × 0.25 μm) with FID detector. The injector temperature was 220 ℃, and the detector temperature was 300 ℃. The column temperature was risen from 70 ℃ to 140 ℃ by program at the rate of 10 ℃/min. Nitrogen was used as carrier gas with the flow rate of 4 mL/min. The injection volume was20 μL with 1:50 as split ratio. Quantitation was carried out by internal standard method.Results The linearity range of amantadine hydrochloride was 0.1 — 0.7 mg/mL (r= 0.999 6). The average recovery of amantadine hydrochloride was 99.27% with RSD of 0.66% (n= 9). Conclusion The method is simple, fast, and accurate, which can be used to determine the content of amantadine hydrochloride in Pediatric Paracetamol and Amantadine Hydrochloride Granules.