目的 探究美托洛爾聯(lián)合阿托伐他汀治療老年不穩(wěn)定心絞痛的臨床療效。方法 選擇2012年4月—2014年4月總后勤部廣州離職干部休養(yǎng)所門診部收治的老年不穩(wěn)定心絞痛患者83例，隨機分為治療組（42例）和對照組（41例）。在常規(guī)治療基礎(chǔ)上，對照組口服阿托伐他汀片，2片/次，2次/d。治療組患者在對照組治療基礎(chǔ)上口服酒石酸美托洛爾片，1片/次，2次/d。兩組均連續(xù)治療8周。治療后，對兩組的臨床療效進(jìn)行評價，同時比較兩組患者心絞痛發(fā)作持續(xù)時間及發(fā)作頻率。結(jié)果 治療組和對照組總有效率分別為88.1%、68.3%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者心絞痛發(fā)作持續(xù)時間、發(fā)作頻率均明顯少于治療前，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05）；治療后治療組這兩個觀察指標(biāo)的改善程度優(yōu)于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者的每搏輸出量（SV）、射血分?jǐn)?shù)（EF）均明顯高于同組治療前水平，差異有統(tǒng)計學(xué)意義（P<0.05）；治療后治療組SV、EF高于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 美托洛爾聯(lián)合阿托伐他汀治療老年不穩(wěn)定心絞痛有較好的臨床療效，可有效降低心絞痛發(fā)作持續(xù)時間和發(fā)作頻率，具有一定臨床應(yīng)用價值。

Objective To explore the clinical efficacy of metoprolol combined with atorvastatin in treatment of elderly unstable angina. Methods Elderly patients with unstable angina (83 cases) of Clinic Department of Resthome for Retied Veterans in Guangzhou, General Logistics Department of Chinese PLA April, 2012 to April, 2014 were randomly divided into treatment (n = 42) and control (n = 41) groups. Patients in the control group were po administered with Atorvastatin Tablets on the basis of conventional treatment, 2 pieces/time, twice daily. Patients in the treatment group were po administered with Metoprolol Tartrate Tablets on the basis of control group, one piece/time, twice daily. After treatment, the treatment efficacies in two groups were evaluated, and duration time and frequency of angina attacks in two groups were compared.Results After treatment, the effective rates in the treatment and control groups were 88.1% and 68.3%, respectively, with significant difference between the two groups (P< 0.05). After treatment, duration time and frequency of angina attacks in two groups were significantly less than those before the treatment, with statistically significant difference before and after treatment in the same group (P< 0.05). Those detection indexes in the treatment group were improved better than those in the control group, with statistically significant difference (P< 0.05). After treatment, the SV and EF in two groups were significantly higher than those before the treatment, with statistically significant difference before and after treatment in the same group (P< 0.05). SV and EF in the treatment group were higher than those in the control group after treatment, with statistically significant difference (P< 0.05). Conclusion Metoprolol combined with atorvastatin has a good clinical efficacy in treatment of elderly unstable angina, and can effectively reduce the duration time and frequency of angina attacks, which has a certain clinical application value.

國家自然科學(xué)基金資助項目（81070196）