T型鈣通道是一種低電壓鈣通道，在體內(nèi)分布廣泛，參與多種生理過程。T型鈣通道阻滯劑是目前關(guān)注較多的一種新型鈣通道阻滯劑，除具備與傳統(tǒng)鈣通道阻滯劑相似的降壓作用外，還具有如降低心肌自律性、抗心肌重塑、保護(hù)腎功能、抗交感神經(jīng)等藥理作用。對(duì)T型鈣通道阻滯劑的藥理作用、藥物相互作用與不良反應(yīng)等研究進(jìn)展進(jìn)行綜述，從而了解T型鈣通道阻滯劑在臨床實(shí)踐中的應(yīng)用現(xiàn)狀，探索和開發(fā)其在臨床實(shí)踐中的新使用價(jià)值。

T-type calcium channel is a kind of low voltage calcium channel, widely distributed throughout the body and participates in many physiological activities. Now increasing attention has been focused on the blockers of the T-type calcium channel. It has not only the function of lowing blood pressure like traditional calcium channel blockers, but also some pharmacological activities such as inhibiting cardiac muscle autorhythmicity, anti-cardiovascular remodeling, renal protective action, and resistance to the sympathetic nervous. This paper summarizes the pharmacological activities, drug interaction, and side effects of T-type calcium channel blockers, which helps to understand the application status of the T type calcium channel blockers in clinical practice, and explore and develop new use value of T-type calcium channel blockers.

國(guó)家“重大新藥創(chuàng)制”科技重大專項(xiàng)資助項(xiàng)目（2012ZX09303-008-001）；2010年國(guó)家臨床重點(diǎn)?？平ㄔO(shè)項(xiàng)目