1H-NMR確證了結構, 此路線所得產品收率為18.2%, 質量分數(shù)為99.17%。同時得到了一條由化合物4合成化合物7的新路線, 大幅度提高了合成化合物7的收率。結論 得到了一條合成lesinurad的實用路線, 并獲得了一種產率更高的合成重要中間體7的新方法。;Objective To find a practical synthetic route of uric acid transporter 1 (URAT1) inhibitor lesinurad. Methods 1-Bromonaphthalene and cyclopropylmagnesium bromide were used as starting materials. The target compound lesinurad was synthesized by 10 steps. The synthetic route of the intermediate 3-amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (7) starting from 4-cyclopropylnaphthalen-1-yl isothiocyanate (4) was studied with expectation of improving yield. Results The target compound was synthesized and characterized by IR, MS, and 1H-NMR. The overall yield of this route was 18.2%, and the purity was 99.17%. A new synthetic route of compound 7 starting from compound 4 was developed with significantly improved yield. Conclusion A practical synthetic route of lesinurad is obtained. A new synthetic route of the key intermediate 7 is developed with significantly improved yield."/>