目的 觀察固腎1號(hào)對(duì)大鼠抗腎小球基底膜(GBM)腎炎的治療作用,并探討其作用機(jī)制。方法 采用尾iv兔GMB血清免疫大鼠,制作大鼠Masugi腎炎實(shí)驗(yàn)?zāi)Ｐ?。給藥3周,觀察固腎1號(hào)對(duì)大鼠尿蛋白含量、血液生化、腎臟系數(shù)、腎臟病理以及大鼠IgG、兔IgG在腎小球基底膜上沉積的影響。結(jié)果 固腎1號(hào)能顯著降低尿蛋白含量,降低血清尿素氮(BUN)、肌酐(Cr)水平,升高血清總蛋白(Tp)、白蛋白(Alb)水平,并能降低腎臟系數(shù),減輕腎臟病理改變及大鼠免疫球蛋白G(IgG)、兔IgG在腎小球基底膜上的沉積。結(jié)論 固腎1號(hào)能通過減少大鼠IgG、兔IgG在腎小球基底膜上的沉積,減輕腎臟病變,改善腎功能。

Objective To investigate the therapeutic effect of Gushen No. 1 on rat anti glomerular basement membrane (GBM) nephritis of rats, and study its possible mechanisms. Methods Rat anti-GBM antibody produced in rabbit was injected to rats to make Masugi nephritis model. After 3 weeks, index was observed after administrated Gushen No. 1, such as on urine protein, blood biochemistry, kidney index, kidney pathology, and IgG of rats and rabbit in GBM. Results Gushen No. 1 could significantly reduce rat's urine protein, serum urea nitrogen (BUN), serum creatinine (Cr), increase serum total protein (TP), and albumin (Alb). It also had therapeutic on significant reducing of renal index, improvement of kidney pathology, and reducing IgG of rats and rabbit in GBM. Conclusion It is obvious that Gushen No. 1 can alleviate kidney lesions and improve kidney function by reducing IgG of rats and rabbit in GBM.