目的 研究中山市陳星海醫(yī)院鮑曼不動桿菌的分布及耐藥性,為合理用藥提供參考.方法 對2012—2014年中山市陳星海醫(yī)院鮑曼不動桿菌的分布及耐藥情況進行回顧性統(tǒng)計分析.結果 共分離出461株鮑曼不動桿菌,其標本的主要來源為痰液,其次為分泌物和引流液.感染區(qū)分布主要為重癥監(jiān)護病房,其次為老年綜合科和呼吸內科.鮑曼不動桿菌對頭孢唑林、頭孢替坦、磷霉素、厄他培南、美洛培南、氨芐西林、呋喃妥因、強力霉素的耐藥性較強,對頭孢哌酮/舒巴坦、阿米卡星和多黏菌素B的耐藥性弱,而且鮑曼不動桿菌的耐藥性逐年遞增.結論 鮑曼不動桿菌對多種抗菌藥物具有較高的耐藥性,應該加強其耐藥性的監(jiān)控,選擇合適的藥物進行治療.對于感染的高危科室和高危部位,應重點防控.

Objective To study the distribution and drug resistance of Acinetobacter baumannii in Zhongshan Chen-Xinghai Hospital, and provide reference for rational drug use. Methods The distribution and drug resistance of A. baumannii in Zhongshan Chen-Xinghai Hospital from 2012 to 2014 were reviewed, retrospectively. Results Totally 461 strains of bacteria were isolated. The specimens were mainly obtained from the sputum. The minority was from secretions and drained fluid. The infections distributed widely in intensive care unit, followed by elderly general department and respiratory department. The resistance of A. baumannii against cefazolin, cefotetan, fosfomycin, ertapenem, meropenem, ampicillin, macrodantin, and doxycycline was high. The resistance against cefoperazone/sulbactam, amikacin, and polymyxin B was low. And the drug resistance of A. baumannii increased year by year. Conclusion A. baumannii has higher resistance to many kinds of antibacterial drugs. The monitoring of drug resistance should be strengthened, and appropriate drugs should be chosen for treatment. High-risk departments and parts of infection should be focused on prevention and control.