目的 對鹽酸維拉佐酮的合成工藝進行研究.方法 以5-氰基吲哚為起始原料,通過傅克反應、還原反應、磺酰化反應、縮合反應得到維拉佐酮,然后與鹽酸反應得到鹽酸維拉佐酮.結果 合成了目標化合物,并利用¹H-NMR、MS 確證了結構.此路線的總收率為47.89%,質量分數為99.66%.結論 該合成工藝設計合理,操作簡單,適用于工業(yè)化生產,鹽酸維拉佐酮的收率和純度較高.

Objective To study the synthetic technology of vilazodone hydrochloride. Methods 5-Cyanoindole was used as starting material to synthesize vilazodone by Friedel-Craft reaction, reduction reaction, sulfonylation reaction, and condensation reaction. Then vilazodone hydrochloride was synthesized by reacting with hydrochloric acid. Results The target compound was synthesized and characterized by ¹H-NMR and MS. The total yield of vilazodone hydrochloride with the purity of 99.66% was 47.89%. Conclusion The synthetic route of vilazodone hydrochloride has the advantages of reasonable design and simple operation with high yield and purity, and is suitable for industrial production.