目的 研究紅景天苷對(duì)鏈脲佐菌素誘導(dǎo)糖尿病大鼠血糖、血脂和抗氧化能力的影響。方法 采用ip鏈脲佐菌素(60 mg/kg)制備糖尿病大鼠模型;取造模成功的糖尿病大鼠50只,根據(jù)血糖值水平隨機(jī)分為模型組、二甲雙胍(25 mg/kg)組和紅景天苷(25、50、100 mg/kg)組,每組10只,并另設(shè)對(duì)照組。ig給藥體積均為1 mL/kg,1次/d,連續(xù)給藥12周。分別于給藥前和治療后第4、8、12周測(cè)定各組大鼠空腹血糖和胰島素水平。給藥治療12周后,分別稱量各組大鼠體質(zhì)量。測(cè)定血清中總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的水平以及血清中總抗氧化能力(T-AOC)水平,超氧化物歧化酶(SOD)、谷胱甘肽過氧化物酶(GSH-Px)、過氧化氫酶(CAT)的活性和丙二醛(MDA)含量。結(jié)果 與模型組比較,紅景天苷50、100 mg/kg組糖尿病大鼠體質(zhì)量明顯增加,血清中TC水平和MDA含量顯著降低(P <0.05、0.01);與模型組比較,紅景天苷25、50、100 mg/kg組糖尿病大鼠血清中TG、LDL-C水平顯著降低且HDL-C水平顯著升高(P <0.05、0.01),T-AOC水平和SOD、CAT活性均顯著升高(P <0.05、0.01);與模型組比較,紅景天苷100 mg/kg組糖尿病大鼠空腹血糖水平顯著降低且胰島素水平顯著升高(P <0.01),GSH-Px活性顯著升高(P <0.05)。結(jié)論 紅景天苷能夠有效降低鏈脲佐菌素誘導(dǎo)糖尿病大鼠的血糖和血脂,并提高機(jī)體抗氧化能力。

Objective To study the effects of salidroside on blood sugar, plasma lipid, and antioxidant ability in diabetic rats induced by streptozocin. Methods Diabetic model rats were made by ip administration with streptozocin (50 mg/kg). According to blood glucose levels, a total of 50 diabetic rats were randomly divided into model group, metformin (25 mg/kg) group, and salidroside (25, 50, and 100 mg/kg) groups. Each group had 10 rats. And other 10 rats were selected into control group. Rats were ig administered with dosage of 1 mL/kg, and the treatment was adopted once daily and lasted for 12 weeks. The level of fasting blood sugar and insulin in rats were determined before treatment and treated for 4, 8, and 12 weeks. After treatment for 12 weeks, the body weights of rats were determined. The content of TC, TG, LDL-C, HDL-C in serum, the level of T-AOC in serum, the activity of SOD, GSH-Px, CAT, and the content of MDA in serum were determined. Results Compared with model group, the body weights of rats in salidroside (50 and 100 mg/kg) groups were obviously increased, and TC level and MDA contents in serum were significantly decreased (P < 0.05, 0.01). Compared with model group, the levels of TG and LDL-C in serum of rats in salidroside (25, 50, and 100 mg/kg) groups were significantly decreased, but HDL-C level was obviously increased (P < 0.05, 0.01), the level of T-AOC in serum and the activity of SOD and CAT were significantly increased (P < 0.05, 0.01). Compared with model group, the level of fasting blood sugar of rats in salidroside (100 mg/kg) group was significantly decreased, but the level of insulin was significantly increased (P < 0.01), the activity of GSH-Px was obviously increased (P < 0.05). Conclusion Salidroside could effectively lower the blood sugar and plasma lipid, and improve antioxidant ability.