目的 探討穩(wěn)心顆粒聯(lián)合瑞舒伐他汀治療不穩(wěn)定型心絞痛的臨床療效。方法 收集2012年1月—2014年2月新疆維吾爾自治區(qū)胸科醫(yī)院收治的不穩(wěn)定型心絞痛患者280例,隨機(jī)分為對(duì)照組和治療組,每組各140例。對(duì)照組在常規(guī)治療基礎(chǔ)上口服瑞舒伐他汀鈣片,10 mg/次,1次/d。治療組在對(duì)照組基礎(chǔ)上口服穩(wěn)心顆粒9 g/次,3次/d。兩組均連續(xù)治療24周。觀察兩組的臨床療效,比較兩組紅細(xì)胞壓積、全血黏度、纖維蛋白原及C反應(yīng)蛋白(CRP)等血液流變學(xué)指標(biāo)的變化,同時(shí)比較兩組不穩(wěn)定型心絞痛的發(fā)生頻率及持續(xù)時(shí)間。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為82.14%、92.86%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P <0.05)。治療后,兩組患者紅細(xì)胞壓積、全血黏度、纖維蛋白原及CRP均顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P <0.05);治療后治療組這些觀察指標(biāo)的下降程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P <0.05)。兩組患者治療后發(fā)作頻率與持續(xù)時(shí)間均顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P <0.05);治療后治療組這些觀察指標(biāo)的下降程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P <0.05)。結(jié)論 穩(wěn)心顆粒聯(lián)合瑞舒伐他汀治療不穩(wěn)定型心絞痛具有較好的臨床療效,可顯著降低患者血液流變學(xué)指標(biāo),明顯改善患者不穩(wěn)定型心絞痛發(fā)作頻率與持續(xù)時(shí)間,具有一定的臨床應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Wenxin Granule combined with rosuvastatin in treatment of unstableangina.Methods Patients (280 cases) with unstable angina in Chest Hospital of Xinjiang Uygur Autonomous Region from January 2012 to February 2014 were randomly divided into control and treatment groups, and each group had 140 cases. The patients in the control group were po administered with Rosuvastatin Calcium Tablets on the basis of conventional treatment, 10 mg/time, once daily. The patients in the treatment group were po administered with Wenxin Granule on the basis of the control group, 9 g/time, three times daily. Two groups were treated for 24 weeks. After treatment, the efficacy was evaluated, and the changes of blood rheology indexes such as red blood cells deposited, whole blood viscosity, fibrinogen and C-reactive protein (CRP) in two groups were compared. At the same time, unstable angina frequency and duration in the two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 82.14% and 92.86%, respectively, and there was difference between two groups (P < 0.05). After treatment, red blood cells deposited, whole blood viscosity, fibrinogen, and CRP in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Unstable angina frequency and duration in two groups were significantly lower, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Wenxin Granule combined with rosuvastatin has good clinical efficacy in treatment of unstable angina, and can significantly reduce blood rheology indexes, also can significantly improve unstable angina attack frequency and duration, which has certain clinical application value.