目的 研究雷公藤多苷聯(lián)合潑尼松治療亞急性甲狀腺炎的臨床療效。方法 選取2013年12月—2014年8月日照市婦幼保健院內(nèi)科收治的亞急性甲狀腺炎患者104例,隨機(jī)分為對(duì)照組和治療組,每組各52例。對(duì)照組患者口服醋酸潑尼松片30 mg/d,應(yīng)用1周以后進(jìn)行減量,每周降低5 mg,最后維持5 mg/d。治療組在對(duì)照組治療的基礎(chǔ)上口服雷公藤多苷片2片/次,3次/d。兩組均連續(xù)治療2個(gè)月。觀察兩組的臨床療效,同時(shí)比較兩組退熱時(shí)間、甲狀腺縮小時(shí)間、血沉恢復(fù)時(shí)間及復(fù)發(fā)率。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為78.85%、92.31%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P <0.05)。治療組退熱時(shí)間、甲狀腺縮小時(shí)間以及血沉恢復(fù)時(shí)間均顯著短于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P <0.05)。隨訪6個(gè)月期間,對(duì)照組和治療組的復(fù)發(fā)率分別為17.31%、3.85%,兩組復(fù)發(fā)率比較差異具有統(tǒng)計(jì)學(xué)意義(P <0.05)。結(jié)論 雷公藤多苷聯(lián)合潑尼松治療亞急性甲狀腺炎具有較好的臨床療效,可顯著改善患者的臨床癥狀,降低復(fù)發(fā)率,且無顯著不良反應(yīng),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical curative effect of tripterygium glycosides combined with prednisone in treatment of subacute thyroiditis. Methods Patients (104 cases) with subacute thyroiditis in Maternal and Child Health Care of Rizhao City from December 2013 to August 2014 were randomly divided into control and treatment groups, and each group had 52 cases. The patients in the control group were po administered with Prednisone Acetate Tablets 30 mg/d, the dosage was reduced 5 mg weekly after one week, and finally the dosage was maintained 5 mg/d. The patients in the treatment group were po administered with Tripterygium Glycosides Tablets, 2 tablets/time, three times daily. Two groups were treated for eight weeks. After treatment, the efficacy was evaluated, and the defervescence time, time of thyroid gland to reduce, blood sedimentation recovery time and recurrence rate in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 78.85% and 92.31%, respectively, and there was difference between two groups (P < 0.05). After treatment, the defervescence time, time of thyroid gland to reduce, and blood sedimentation recovery time in treatment group were shorter than those in the control group, with significant differences between two groups (P < 0.05). During the follow-up of six months, recurrence rate in control and treatment groups were 17.31% and 3.85%, respectively, and there was difference between two groups (P < 0.05). Conclusions Tripterygium glycosides combined with prednisone has good clinical curative effect in treatment of subacute thyroiditis, and can significantly improve the clinical symptoms with no significant adverse reactions, and also can reduce the recurrence rate, which has a certain clinical application value.