目的 探究羥氯喹聯(lián)合他克莫司軟膏治療面部激素依賴性皮炎的臨床療效。方法 選取2013年3月—2014年9月襄陽市中心醫(yī)院皮膚科門診收治的面部激素依賴性皮炎患者73例,隨機分為對照組(36例)和治療組(37例)。兩組患者皆外用0.1%他克莫司軟膏于患處,2次/d。對照組口服鹽酸左西替利嗪片,5 mg/次,1次/d。治療組口服硫酸羥氯喹片,0.2 g/次,2次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組的反跳發(fā)生率。結(jié)果 治療后,對照組和治療組的總有效率分別為80.56%、100.00%,兩組比較差異具有統(tǒng)計學(xué)意義(P <0.05)。治療后,兩組癥狀總評分均較治療前顯著下降,同組治療前后差異有統(tǒng)計學(xué)意義(P <0.05);且治療組的下降程度優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P <0.05)。對照組和治療組反跳發(fā)生率分別為5.56%、0,兩組比較差異具有統(tǒng)計學(xué)意義(P <0.05)。結(jié)論 羥氯喹聯(lián)合他克莫司軟膏治療面部激素依賴性皮炎具有較好的臨床療效,且反跳發(fā)生率低,具有一定的臨床推廣應(yīng)用價值。

Objective To observe the clinical curative effect of hydroxychloroquine combined with Tacrolimus Ointment in treatment of facial hormone dependent dermatitis. Methods Patients (73 cases) with facial hormone dependent dermatitis in dermatology outpatient service of Xiangyang Centre Hospital from March 2013 to September 2014 were randomly divided into control (n= 36) and treatment (n= 37) groups. Patients in two groups were external used 0.1% Tacrolimus Ointment in the affected area, twice daily. The patients in the control group were po administered with Levocetirizine Hydrochloride Tablets, 5 mg/time, once daily. The patients in the treatment group were po administered with Hydroxychloroquine Sulfate Tablets, 0.2 g/time, twice daily. Two groups were treated for four weeks. After treatment, the efficacy was evaluated, and the bounce rate in two groups was compared. Result After treatment, the efficacies in the control and treatment groups were 80.56% and 100.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, symptoms total score in two groups were significant reduced, and the difference was statistically significant in the same group (P < 0.05). And the reducing degree in treatment group was better than that in the control group, with significant differences between two groups (P < 0.05). The bounce rate in the control and treatment groups were 5.56% and 0, respectively, and there were differences between two groups (P < 0.05). Conclusion Hydroxychloroquine combined with Tacrolimus Ointment has good clinical efficacy in treatment of facial hormone dependent dermatitis with low bounce rate, which has a certain clinical application value.