目的 探討3種微生態(tài)制劑治療嬰兒腹瀉的臨床療效。方法 選擇2013 年5 月—2015 年1 月天津市第一醫(yī)院收治的非感染性腹瀉患兒120 例,隨機分為布拉氏酵母菌組、酪酸梭腸球菌組和枯草桿菌組,每組各40 例。布拉氏酵母菌組患兒口服布拉氏酵母菌散,<1 個月,0.125 g/次,2 次/d;≥1 個月,0.25 g/次,1 次/d。酪酸梭腸球菌組口服酪酸梭腸球菌三聯(lián)活菌片,<1 個月,0.05 g/次,3次/d;≥1 個月,0.07 g/次,3次/d?？莶輻U菌組口服枯草桿菌二聯(lián)活菌顆粒,<1 個月,0.5 g/次,2 次/d;≥1 個月,1.0 g/次,2 次/d。3 組患兒均連續(xù)治療5 d。觀察3 組患兒的臨床療效、腹瀉次數(shù)、腹瀉好轉時間及脫水情況。結果 布拉氏酵母菌組、酪酸梭腸球菌組和枯草桿菌組的總有效率分別為95.0%、75.0%、72.5%,布拉氏酵母菌組的總有效率顯著高于其他兩組,差異具有統(tǒng)計學意義(P <0.05)。治療后,布拉氏酵母菌組的腹瀉次數(shù)及腹瀉好轉時間明顯短于其他兩組,且布拉氏酵母菌的脫水情況輕于其他兩組,差異具有統(tǒng)計學意義(P <0.05)。結論 布拉氏酵母菌治療嬰兒非感染性腹瀉臨床效果較好,可縮短患兒的腹瀉病程,值得臨床推廣應用。

Objective To explore the clinical curative effect of three kinds of probiotics in treatment of infantile noninfectious diarrhea.Methods Patients (120 cases) with noninfectious diarrhea in the First Hospital of Tianjin from May 2013 to January 2015 were randomly divided into saccharomyces boulardii, clostridium butyricum, and bacillus subtilis groups, and each group had 40 cases. The patients in saccharomyces boulardii group were po administered with Saccharomyces Boulardii Sachets,<1 month 0.125 g/time, twice daily;≥1 month 2.5 g/time, once daily. The patients in clostridium butyricum group were po administered with Laosuan Spindle Enterococcus Triple Viable Tablets,<1 month 0.05 g/time, three times daily;≥1 month 0.07 g/time, three times daily. The patients in bacillus subtilis group were po administered with Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,<1 month 0.5 g/time,twice daily;≥1 month 1.0 g/time, twice daily. Two groups were treated for 5 d. After treatment, the efficacy, diarrhea frequency, diarrhea turnaround time, and dehydrated situation in three groups were observed. Results After treatment, efficacies in saccharomyces boulardii,clostridium butyricum, and bacillus subtilis groups were 95.0%, 75.0%, and 72.5%, and the efficacies in saccharomyces boulardii group was obviously higher than those in the other two groups, and the difference was statistically significant (P<0.05). After treatment, diarrhea frequency and diarrhea turnaround time in saccharomyces boulardii group was obviously shorter than those in the other two groups, and dehydration in saccharomyces boulardii group was lighter than that in the other two groups, and the difference was statistically significant(P<0.05). Conclusion Saccharomyces boulardii has good clinical effect in treatment of infantile noninfectious diarrhea, and can shorten the diarrhea duration, which is worthy of clinical popularization and application.