目的 考察鹽酸曲馬多注射液與硫酸鎂注射液配伍的穩(wěn)定性,為臨床用藥安全提供依據(jù)。方法 模擬臨床用藥方案,觀察鹽酸曲馬多與硫酸鎂注射液在0.9%氯化鈉注射液配伍后,在168 h內(nèi)的外觀、pH值及不溶性微粒變化,并采用高效液相色譜法測定鹽酸曲馬多質(zhì)量濃度的變化。結(jié)果 配伍液在室溫條件下外觀、pH值及不溶性微粒均無明顯變化,兩藥配伍后鹽酸曲馬多相對質(zhì)量濃度>99%。結(jié)論 鹽酸曲馬多注射液與硫酸鎂注射液在0.9%氯化鈉注射液配伍后,在室溫條件下168 h可保持穩(wěn)定。

Objective To investigate the stability of Tramadol Hydrochloride Injection combined with Magnesium Sulfate Injection in 0.9% sodium chloride injection, to provide an experimental basis for clinical drug safety. Methods According to the common concentration and preparation methods used in clinic, the appearance, pH values, and insoluble particles in combined solution were observed within 168 h, and the concentrations were determined by HPLC method after combination of tramadol with magnesium sulfate. Results No obvious change was found in the appearance, pH values and insoluble particles of the mixtures at room temperature. The contents of tramadol hydrochloride were above 99%. Conclusion Tramadol Hydrochloride Injection combined with Magnesium Sulfate Injection are stable in 0.9% sodium chloride injection under room temperature within 168 h.

湖北省衛(wèi)生計生科研基金項目(WJ2015MB290)