目的 探討氟哌噻噸美利曲辛治療頑固性高血壓伴焦慮抑郁的療效觀察。方法 105例頑固性高血壓患者均為武邑縣人民醫(yī)院2012年1月—2014年12月門診及住院患者,按照隨機原則分為對照組和治療組,其中對照組52例,治療組53例。兩組患者均采用常規(guī)治療。對照組患者采用3種或以上不同作用機制的降壓藥,其中苯磺酸左旋氨氯地平片,5 mg/次,1次/d;氫氯噻嗪片,25 mg/次,1次/d;馬來酸依那普利片,5 mg/次,1次/d。治療組在對照組基礎上加用氟哌噻噸美利曲辛片,10.5 mg/次,2次/d,早、午各1次口服。兩組患者均連續(xù)治療8周。觀察兩組患者治療后的臨床療效,對血壓的控制水平情況進行監(jiān)測,同時對治療前后的漢密爾頓焦慮量表(HAMA)、漢密爾頓抑郁量表(HAMD)評分進行比較。結果 兩組患者治療后對照組總有效率為78.84%,治療組為94.33%,兩組總有效率比較差異具有統(tǒng)計學意義(P< 0.05)。治療組治療后各時間段血壓控制水平、HAMD、HAMA評分顯著優(yōu)于對照組(P< 0.05)。結論 常規(guī)治療基礎上加用氟哌噻噸美利曲辛片后,血壓參數(shù)明顯改善,平均收縮壓和舒張壓明顯降低,緩解長期高血壓引起的抑郁焦慮癥狀,不良反應少,具有一定的臨床推廣應用價值。

Objective To investigate flupentixol and melitracen in treatment of resistant hypertension with anxiety and depression. Methods Outpatients and inpatients (105 cases) with resistant hypertension in Hospital of Wuyi County from January 2012 to December 2014 were randomly divided into control group (52 cases) and treatment group (53 cases). Patients in two groups were treated with conventional therapy. And patients in control groups were treated with three or more antihypertensive agents with various mechanisms, including Benzene Sulfonic Acid L-amlodipine Tablets, 5 mg/time, twice daily; Hydrochlorothiazide Tablets, 25 mg/time, once daily; Enalapril Maleate Tablets, 5 mg/time, once daily. The patients in the treatment group were po administered with Flupentixol and Melitracen Tablets at breakfast time and lunch time on the basis of control group, 10.5 mg/time, twice daily. Two groups were treated for 8 weeks. After treatment, the efficacy was evaluated, blood pressure control levels were monitored, and Hamilton anxiety scale (HAMA) and Hamilton depression rating scale (HAMD) scores were compared. Results After treatment, the efficacies in the control and treatment groups were 78.84% and 94.33%, respectively, and there was difference between two groups (P < 0.05). After treatment, blood pressure control levels, HAMD score, and HAMA score improvement were significantly better than those of the control group (P < 0.05) Conclusion Flupentixol and Melitracen Tablets added on conventional therapy in treatment of resistant hypertension with anxiety and depression has better improvement on blood pressure, decreases mean systolic blood pressure and diastolic blood pressure, and relieves the symptoms of depression and anxiety caused by long-term hypertension with low incidence of adverse reactions, which has a certain clinical application value.

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