目的 探討宮血寧膠囊聯(lián)合去氧孕烯炔雌醇片治療功能性子宮出血的療效。方法 選擇聊城市第二人民醫(yī)院2013年1月—2014年12月收治的子宮出血患者80例,隨機(jī)分為治療組和對(duì)照組,每組各40例,對(duì)照組患者在術(shù)后第一次來(lái)月經(jīng)的5 d之內(nèi),口服去氧孕烯炔雌醇片150 mg,于20～30 d后再口服1次,此后依次間隔同樣時(shí)間連續(xù)口服6次。治療組在對(duì)照組的基礎(chǔ)上,術(shù)后7 d開(kāi)始服用宮血寧膠囊,4粒/次,3次/d,連續(xù)服用6個(gè)月。所有患者均隨訪3年。比較兩組患者的臨床療效,黃體生成素(LH)、卵泡刺激素(FSH)及雌二醇(E2)水平,以及控制出血時(shí)間與完全止血時(shí)間,同時(shí)比較兩組患者的不良反應(yīng)發(fā)生情況。結(jié)果 治療組患者的有效率為97.5%,明顯高于對(duì)照組(77.5%),兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05)。兩組患者治療后血清中LH、FSH、E2水平均較同組治療前明顯降低,比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05);對(duì)照組和治療組治療后的各激素水平比較差異無(wú)統(tǒng)計(jì)學(xué)意義。兩組患者治療后中醫(yī)證候積分均較同組治療前明顯下降,且治療組治療后的下降程度明顯高于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。治療組患者控制出血時(shí)間與完全止血時(shí)間均較對(duì)照組短,比較差異均具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。治療組患者的不良反應(yīng)發(fā)生率為7.5%,與對(duì)照組比較差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 宮血寧膠囊聯(lián)合去氧孕烯炔雌醇片治療子宮出血療效顯著,可有效改善患者激素水平及中醫(yī)癥狀,值得臨床推廣應(yīng)用。

Objective To investigate the effect of Gongxuening Capsules combined with Desogestrel Ethinylestradiol Tablets in treatment of uterine hemorrhage. Methods Patients (80 cases) with metrorrhagia in The Second People's Hospital of Liaocheng from January 2013 to December 2014 were randomly divided into control and treatment groups. Each group had 40 cases. Patients in control group were oral administrated with Desogestrel Ethinylestradiol Tablets 150 mg for the first time within 5 d forthcoming menstruation after operation, another oral administration after 20—30 d. Then continuous oral administration were given with same time interval in turn for six times. On the basis of control group, patients in treatment group were given Gongxuening Capsules after operation, 4 grains/time, three times daily. Two groups were treated for 6 months, and 3 years was followed up. The clinical efficacy, the levels of luteinizing hormone (LH), follicle stimulation hormone (FSH), and estradiol (E2), the time of control bleeding and complete hemostasis, and adverse drug reactions in two groups were compared. Results The effective rate of patients in treatment group was 97.5%, significantly higher than 77.5% of control group with significant difference (P < 0.05). After treatment, the levels of LH, FSH, and E2 in two groups were significantly lower than those before treatment, and the difference was statistically significant (P < 0.05); There was no significant difference in the hormone levels after treatment between two groups. The TCM syndrome scores of two groups were significantly decreased after treatment, and the degree of treatment group was significantly higher than that of control group with significant difference (P < 0.05). The incidence of adverse drug reactions in treatment group was 7.5%, and there was no significant difference with that of control group. Conclusion Gongxuening Capsules combined with Desogestrel Ethinylestradiol Tablets has significant effect in treatment of metrorrhagia, and can promote the hormone level and TCM symptoms of patients effectively, which is worthy of clinical application.