目的 探究標(biāo)準(zhǔn)桃金娘油腸溶膠囊聯(lián)合頭孢米諾治療急性化膿性鼻竇炎的臨床療效。方法 選取2012年1月—2014年12月亳州市人民醫(yī)院耳鼻喉科收治的急性化膿性鼻竇炎患者80例,隨機分為對照組和治療組,每組各40例。對照組患者靜脈滴注注射用頭孢米諾鈉,1 g/次,加到20 mL生理鹽水中,2次/d。治療組在對照組基礎(chǔ)上口服標(biāo)準(zhǔn)桃金娘油腸溶膠囊,1粒/次,3次/d。兩組均連續(xù)治療6周。觀察兩組的臨床療效,同時比較兩組治療前后鼻腔黏膜纖毛傳輸時間的變化。隨訪3個月,計算兩組的復(fù)發(fā)率。結(jié)果 治療后,對照組和治療組的總有效率分別為77.5%、92.5%,兩組比較差異有統(tǒng)計學(xué)意義(P< 0.05)。治療1、6周后兩組鼻腔黏膜纖毛傳輸時間均有明顯下降,同組治療前后差異具有統(tǒng)計學(xué)意義(P< 0.05);且治療組的下降程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05)。對照組和治療組的復(fù)發(fā)率分別為15%、5%,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05)。結(jié)論 標(biāo)準(zhǔn)桃金娘油腸溶膠囊聯(lián)合頭孢米治療急性化膿性鼻竇炎的具有較好的臨床療效,明顯縮短了鼻腔黏膜纖毛傳輸時間,具有較高的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Myrtol Standardized Enteric Coated Soft Capsules combined with cefminox in treatment of acute suppurative sinusitis. Methods Patients (80 cases) with acute suppurative sinusitis in Department of Otolaryngology of the People's Hospital of Bozhou from January 2012 to December 2014 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Cefminox Sodium for injection, 1 g/time which added into physiological saline 20 mL, twice daily. The patients in the treatment group were po administered with Myrtol Standardized Enteric Coated Soft Capsules on the basis of the control group, 1 grain/time, three times daily. The patients in two groups were treated for 6 weeks. After treatment, the efficacy was evaluated, the changes of nasal mucosa cilia transmission time before and after treatment in two groups were compared. Follow-up of 3 months, the recurrence rates in two groups were calculated. Results After the treatment, the efficacies in the control and treatment groups were 77.5% and 92.5%, respectively, and there was difference between two groups (P < 0.05). After treatment, nasal mucosa cilia transmission times in two groups were significantly reduced after 1 and 6 weeks, and the difference was statistically significant in the same group (P < 0.05). The reduced degree in the treatment group was better than that in the control group, with significant difference between two groups (P < 0.05). The recurrence rates in the control and treatment groups were 5% and 15%, respectively, and there was difference between two groups (P < 0.05). Conclusion Myrtol Standardized Enteric Coated Soft Capsules combined with cefminox has good clinical efficacy in treatment of acute suppurative sinusitis, and can significantly shorten the nasal mucosa cilia transmission time, which has high clinical application value.