目的 觀察三拗片聯(lián)合桉檸蒎腸溶軟膠囊治療急性支氣管炎的臨床療效。方法 將118例急性支氣管炎患者隨機分為治療組和對照組,每組各59例。對照組患者予桉檸蒎腸溶軟膠囊,0.3 g/次,3次/d,餐前0.5 h涼開水送服,治療組在對照組基礎(chǔ)上同時加服三拗片,1.0 g/次,3次/d。治療7 d后,比較兩組的臨床療效、咳嗽咳痰情況、中醫(yī)證候總積分以及不良反應(yīng)情況。結(jié)果 治療后,對照組和治療組的總有效率分別為72.88%、89.83%,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05);治療組咳嗽、咳痰癥狀起效時間明顯早于對照組(P< 0.05);兩組中醫(yī)證候總積分均較治療前顯著下降,同組治療前后差異有統(tǒng)計學(xué)意義(P< 0.05);而兩組不良反應(yīng)發(fā)生情況比較無統(tǒng)計學(xué)意義。結(jié)論 三拗片聯(lián)合桉檸蒎腸溶軟膠囊治療急性支氣管炎具有較好的臨床療效,值得臨床進一步推廣應(yīng)用。

Objective To observe the clinical curative effect of San'ao Tablets combined with Eucalyptol Linonene Pinene Enteric Soft Capsule in treatment of acute bronchitis. Methods Patients (118 cases) with acute bronchitis were randomly divided into treatment group and control group. Each group had 59 cases. Patients in the control group were treated with Eucalyptol Linonene Pinene Enteric Soft Capsule, 0.3 g/time, 3 times/d, half an hour before dinner with cold boiled water. On the basis of control group, patients in the treatment group were treated with San'ao Tablets, 1.0 g/time, 3 times/d. After treatment for 7 d, the clinical efficacy, cough and expectoration, traditional Chinese medicine (TCM) syndrome total scores, and adverse reaction conditions were compared. Results After treatment, the efficacies in the control and treatment groups were 72.88% and 89.83%, respectively, and there were significant differences between two groups (P < 0.05). The onset time of cough and expectoration symptoms in treatment group was significantly earlier than that in control group (P < 0.05). After treatment, total scores of TCM syndrome in treatment group was significantly lower than that in control group (P < 0.05). But there was no significant difference in the adverse reactions. Conclusion San'ao Tablets combined with Eucalyptol Linonene Pinene Enteric Soft Capsule has good clinical curative effect in treatment of acute bronchitis, which has a certain clinical application value.