目的 觀察喜炎平注射液聯(lián)合小兒豉翹清熱顆粒治療兒童急性上呼吸道感染的臨床療效和安全性。方法 選取2015年3月—2015年4月漢中市中心醫(yī)院兒科進行治療的急性上呼吸道感染患兒120例,隨機分為對照組和治療組,每組患兒各60例。對照組給予小兒豉翹清熱顆粒,開水沖服,3次/d,飯后服用,不同年齡組用量不同,6個月～1歲患兒:1～2 g/次;1～3歲患兒:2～3 g/次;4～6歲患兒:3～4 g/次;7～9歲患兒:4～5 g/次。治療組患者采用喜炎平注射液靜脈滴注,1次/d,0.2～0.4 mL/kg,小兒豉翹清熱顆粒的用法、用量同對照組。兩組患兒均連續(xù)治療5 d。觀察兩組的臨床療效,同時比較兩組治療前后主要癥狀、體征消失時間以及血清學指標。結果 治療后治療組和對照組患兒總有效率分別為96.67%、75.00%,兩組總有效率比較差異具有統(tǒng)計學意義(P< 0.05)。治療組患兒退熱時間、腹瀉消失時間、嘔吐消失時間、咳嗽消失時間、鼻塞消失時間和咽痛消失時間均顯著低于對照組患兒,兩組比較差異均具有統(tǒng)計學意義(P< 0.05)。治療后兩組患兒hs-CRP、TNF-α和IL-6較治療前顯著改善,治療前后比較差異具有統(tǒng)計學意義(P< 0.05);治療后治療組患兒hs-CRP、TNF-α和IL-6較對照組患兒有顯著改善,兩組比較差異具有統(tǒng)計學意義(P< 0.05)。兩組患兒在治療期間均未觀察到不良反應。結論 喜炎平注射液聯(lián)合小兒豉翹清熱顆粒治療兒童急性上呼吸道感染臨床療效好,起效快,未發(fā)現(xiàn)不良反應,具有一定的臨床推廣應用價值。

Objective To explore the clinical curative effect and safety of Xiyanping Injection combined with Xiaoer Chiqiao Qingre Granule in treatment of pediatric acute upper respiratory infection. Methods Patients (120 cases) with acute upper respiratory infection in Hanzhong Central Hospital from March 2015 to April 2015 were selected, and they were randomly divided into control group and treatment group, each group with 60 cases. The patients in the control group were po administered with Xiaoer Chiqiao Qingre Granule in boiling water after meals, 3 times daily. The amounts of drugs were corresponding with ages of children, such as six months-6 years children had 1-2 g/time; 1-3 years old, 2-3 g/time; 4-6 years old, 3-4 g/time; 7-9 years old, 4-5 g/times. The patients in treatment group were administered with Xiyanping Injection iv drip, 1 time daily, 0.2-0.4 mL/kg, and the usage of Xiaoer Chiqiao Qingre Granule was the same to control group. Two groups of children were treated for 5 d. The clinical efficacies of the two groups were observed, and the main symptoms, signs, and serology index were compared between two groups. Results The efficacies in the control and treatment groups after treatment were 96.67% and 75%, respectively, and there was difference between two groups (P < 0.05). The disappearing time of fever, diarrhea, vomiting, cough, stuffy nose, and sore throat in the treatment group was significantly lower than children in control group, and the difference between two groups was statistically significant (P < 0.05). IL-6, TNF-α, and hs-CRP were significantly improved in two groups after treatment, and the difference was statistically significant before and after treatment (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Adverse reactions were not observed in the two groups during the treatment period. Conclusion Xiyanping Injection combined with Xiaoer Chiqiao Qingre Granule has good clinical curative effect in treatment of pediatric acute upper respiratory infection, and can significantly improve the clinical symptoms with no significant adverse reactions, which has a certain clinical application value.