目的 觀察疏風(fēng)解毒膠囊治療小兒上呼吸道感染的臨床療效。方法 選取2013年1月至2014年10月上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院收治的上呼吸道感染患兒243例,隨機(jī)分為對照組和治療組,其中對照組118例,治療組125例。兩組患兒均予休息、口服補(bǔ)液、止咳等對癥支持治療,治療組同時(shí)給予疏風(fēng)解毒膠囊,4～6歲,2粒/次;6～10歲,3粒/次;10～13歲,4粒/次。3次/d,口服或溫水沖服,療程7 d。療程內(nèi)達(dá)臨床治愈患兒予以停藥。記錄并比較患兒第1、3、7天白細(xì)胞或中性粒細(xì)胞異常、肺部啰音、胸部X線異常以及體溫正常、咳嗽恢復(fù)、咽部紅腫改善情況。同時(shí)觀察兩組的臨床療效和不良反應(yīng)。結(jié)果 治療第3天,兩組白細(xì)胞或中性粒細(xì)胞異?；純豪龜?shù)比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05);治療第3、7天,兩組肺部啰音、胸部X線異常的患兒例數(shù)差異比較具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。與對照組比較,治療后第1天,治療組患兒體溫正常、咳嗽恢復(fù)情況好于對照組,差異均具有統(tǒng)計(jì)學(xué)意義(P< 0.05);治療后第3、7天,治療組患兒體溫正常、咳嗽恢復(fù)、咽部紅腫改善情況好于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。治療后,治療組總有效率為92.80%,明顯高于對照組的總有效率81.35%,兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。兩組均未出現(xiàn)明顯的不良反應(yīng)。結(jié)論 疏風(fēng)解毒膠囊在常規(guī)治療基礎(chǔ)上治療小兒急性上呼吸道感染具有較好的臨床療效,無明顯不良反應(yīng),具有一定的臨床推廣價(jià)值。

Objective To observe the clinical curative effect of Shufeng Jiedu Capsules in treatment of pediatric acute upper respiratory tract infection. Methods Children (243 cases) with acute upper respiratory tract infection in Longhua Hospital Shanghai University of Traditional Chinese Medicine from January 2013 to October 2014 were randomly divided into control group (118 cases) and treatment group (125 cases). Children in two groups were treated with conventional treatment, such as rest, supplement of fluid, relief of cough, etc. Children in the treatment group were po administered with Shufeng Jiedu Capsules on the basis of conventional treatment, 4-6 years old, 2 grain/time; 6-10 years old, 3 grain/time; 10-13 years old, 4 grain/time; three times daily, po or taken with warm water. Two groups were treated for 7 d, but drugs would be stopped within course when clinical curative effects were obtained. Leukocyte or neutrophil abnormalities, rales, abnormal chest X-ray, normal temperature, cough recovery, and throat swelling improvement were recorded and compared on days 1, 3, and 7. At the same time, the efficacy was evaluated, and adverse reactions were observed. Results On day 3 of treatment, there were differences in cases of leukocyte or neutrophil abnormalities between two groups (P < 0.05). And on days 3 and 7 of treatment, there were differences in cases of rales and abnormal chest X-ray between two groups (P < 0.05). Compared with control group, on day 1 of treatment, condition of normal temperature and cough recovery in treatment group were better than those in control group, with significant differences between two groups (P < 0.05). While on days 3 and 7 of treatment, condition of normal temperature, cough recovery, and throat swelling improvement in treatment group were better than those in control group, with significant differences between two groups (P < 0.05). After treatment, the efficacies in the control and treatment groups were 81.35% and 92.80%, respectively, and there was difference between two groups (P < 0.05). There were no adverse events between two groups. Conclusion Shufeng Jiedu Capsules on the basis of conventional treatment can improve the curative effect of pediatric acute upper respiratory tract infection with no serious adverse reaction, which has a certain clinical value.