目的 探討武漢大學(xué)人民醫(yī)院消化內(nèi)科院內(nèi)獲得性感染病原菌的分布、耐藥性及危險因素分析。方法 選取2012年8月—2015年2月武漢大學(xué)人民醫(yī)院消化內(nèi)科院內(nèi)獲得性耐藥菌感染的住院患者64例,對分離出的病原菌的分布、耐藥性及危險因素分析進(jìn)行分析。結(jié)果 檢出耐藥菌的標(biāo)本主要來源于尿液和痰液;分離出的耐藥菌菌株中革蘭陽性菌20株、革蘭陰性菌44株。革蘭陽性菌除對利奈唑胺敏感外,其余均有不同程度的耐藥;革蘭陰性菌耐藥嚴(yán)重;住院患者院內(nèi)獲得性感染的主要危險因素為年齡、手術(shù)和尿管。結(jié)論 臨床醫(yī)護(hù)人員應(yīng)加強(qiáng)關(guān)注住院患者院內(nèi)獲得性耐藥菌感染的相關(guān)危險因素,預(yù)防感染的發(fā)生,合理使用抗菌藥物。

Objective To study the distribution, drug resistance and risk factors of pathogenic bacteria of hospital acquired infection in Department of Gastroenterology in Renmin Hospital of Wuhan University. Methods Inpatients (64 cases) with hospital acquired infection in Department of Gastroenterology in Renmin Hospital of Wuhan University from August 2012 to February 2015 were selected. The distribution, drug resistance and risk factors of pathogenic bacteria were analyzed. Results The specimens were mainly obtained from urine and sputum. There were 20 strains of Gram-positive bacteria, and 44 strains of Gram-negative bacteria. Gram positive bacteria were sensitive to linezolid, while they were variously resistant to other antibiotic drugs. The resistance of Gram-negative bacteria was serious. The main risk factors of hospital acquired drug resistance bacteria infection was age, surgery and urine tube. Conclusion Clinical medical staff should pay much more attention to related risk factors of pathogenic bacteria of hospital acquired infection, to prevent the happening of bacterial infection, and rationally use antibiotic drugs.

湖北省自然科學(xué)基金面上項(xiàng)目(2013CFB239)