1H-NMR確證了結(jié)構(gòu),此路線總收率為16%;同時得到了上述3個關(guān)鍵步驟的最優(yōu)化的反應(yīng)條件。結(jié)論 得到了一條合成RDEA3170的實用路線。;Objective To find a practical synthetic route of uric acid transporter 1 (URAT1) inhibitor RDEA3170. Methods 3-Bromo-4-chloropyridine and 1,4-dibromonaphthalene were used as starting materials. Three key synthetic steps, synthesis of 4-bromo-1-naphthonitrile (3), synthesis of (4-cyanonaphthalen-1-yl)boronic acid (4) from compound 3, and the Suzuki coupling, were studied for the optimal reaction conditions. Results RDEA3170 was synthesized by 6 steps. The target compound was synthesized and characterized by MS, and 1H-NMR. The overall yield of this route was 16%. The reaction conditions of the three key steps were optimized. Conclusion A practical synthetic route of RDEA3170 is obtained."/>

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首頁 > 過刊瀏覽>2015年第30卷第10期 >2015,30(10):1179-1184. DOI:10.7501/j.issn.1674-5515.2015.10.001
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RDEA3170的合成工藝研究

Synthesis of RDEA3170

發(fā)布日期:2015-10-27