目的 優(yōu)選止咳平喘顆粒處方藥材的提取工藝。方法 以麻黃堿、連翹酯苷A提取率為指標(biāo),以乙醇體積分?jǐn)?shù)、乙醇倍量、提取時(shí)間、提取次數(shù)為因素,采用L₉(3⁴)正交試驗(yàn)對(duì)提取工藝進(jìn)行優(yōu)選。結(jié)果 最佳提取工藝條件為65%乙醇,回流提取2次,每次8倍量,每次1 h。結(jié)論 優(yōu)選的止咳平喘顆粒處方藥材提取工藝條件合理、可行。

Objective To optimize extraction process on Zhike Pingchuang Granula prescription by orthogonal test. Methods With extracting rates of ephedrine and forsythoside A as indexes, meanwhile ethanol concentration, amount of solvent, extraction duration, and extraction times as investigation factors, conditions for extraction process were optimized by L₉(3⁴) orthogonal test. Results The optimum extraction process conditions were as follows: eight volumes of 60% ethanol and reflux extracting for two times with 1 h for each time. Conclusion The optimized extraction technology is reasonable and feasible for Zhike Pingchuang Granula prescription.