目的 觀察頭孢克肟膠囊聯(lián)合鹽酸左氧氟沙星注射液治療老年肺炎的臨床療效。方法 選取2014年2月-2015年2月在上海市浦東醫(yī)院呼吸內科就診的老年肺炎患者106例,隨機分為治療組和對照組,每組各53例。對照組給予靜脈滴注鹽酸左氧氟沙星注射液,0.4 g/次,2次/d。治療組患者在對照組治療基礎上口服頭孢克肟膠囊,200 mg/次,2次/d。療程均為14 d。比較兩組治療前后患者的臨床療效、癥狀改善情況、相關實驗室檢查。結果 治療后,對照組和治療組的總有效率分別為84.91%、96.23%,兩組總有效率比較差異具有統(tǒng)計學意義(P < 0.05)。治療后,治療組患者臨床體征如發(fā)熱、咳嗽、肺部啰音消失時間均顯著短于對照組,差異具有統(tǒng)計學意義(P < 0.05)。治療后,治療組患者X線胸片炎癥吸收、痰培養(yǎng)的臨床控制率、總有效率均顯著優(yōu)于對照組,差異具有統(tǒng)計學意義(P < 0.05)。治療后,兩組血清中C反應蛋白(CRP)、腫瘤壞死因子-α(TNF-α)、白細胞介素-4(IL-4)及白細胞介素-8(IL-8)水平均顯著下降(P < 0.05),并且治療組血清中CRP、TNF-α、IL-4、IL-8水平下降幅度明顯高于對照組(P < 0.05)。結論 頭孢克肟膠囊聯(lián)合鹽酸左氧氟沙星注射液治療老年肺炎可以提高臨床療效,改善癥狀,控制感染,促進炎癥吸收,且安全性較高,具有一定的臨床推廣應用價值。

Objective To observe the effect of Cefixime Capsules combined with Levofloxacin Hydrochloride Injection in the treatment of senile pneumonia. Methods Patients (106 cases) with senile pneumonia from Department of Respiratory Medicine in Shanghai Pudong Hospital from February 2014 to February 2015 were randomly divided into control and treatment groups, and each group had 53 cases. The patients in the control group were iv administered with Levofloxacin Hydrochloride Injection, 0.4 g/time, twice daily. The patients in the treatment group were po administered with Cefixime Capsules on the basis of control group, 200 mg/time, twice daily. Two groups were treated for 14 d. Symptoms improvement, clinical curative effect, and relevant laboratory examination in two groups were observed. Results After treatment, the efficacies in the control and treatment groups were 84.91% and 96.23%, respectively, and there was difference between two groups (P < 0.05). After treatment, symptoms improvements, such as extinction time of fever, cough, and pulmonary rales in the treatment group were obviously shorter than those in the control group with significant differences between two groups (P < 0.05). After treatment, clinical control rats and the efficacies of chest X-ray radiograph inflammation absorption and sputum culture in the treatment group were better than those of control group with significant differences between two groups (P < 0.05). After treatment, levels of CRP, TNF-α, IL-4, and IL-8 were obviously decreased (P < 0.05). And these indicators in treatment group improved better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Cefixime Capsules combined with Levofloxacin Hydrochloride Injection in the treatment of senile pneumonia can improve the clinical curative effect, improve the symptoms, control infection, promote inflammation absorption, and has good safety, which has a certain clinical application value.