目的 研究消癌平注射液聯(lián)合順鉑治療膀胱癌的臨床療效。方法 選取2011年5月到2014年12月來北京中醫(yī)藥大學東方醫(yī)院就診的膀胱癌患者100例,隨機分為對照組和治療組,每組50例。對照組注入注射用順鉑60 mg加40 mL生理鹽水進行局部灌注,每周治療3次,3周為1個周期。治療組在對照組的基礎上給予消癌平注射液,每次2支,1次/d,3周為1個周期。兩組患者均治療3個周期。比較兩組患者治療后近期療效、近期生活質量評分以及藥物的不良反應發(fā)生情況。結果 治療組患者治療后的有效率為90.0%,高于對照組72.0%,差異具有統(tǒng)計學意義(P < 0.05)。治療后治療組患者自覺癥狀、日常生活、社會活動、心理情緒狀態(tài)、軀體生理功能狀態(tài)和總得分均高于對照組,差異有統(tǒng)計學意義(P < 0.05)。治療組患者白細胞降低、血小板減少、惡心嘔吐、脫發(fā)、貧血、皮疹等不良反應發(fā)生率均小于對照組,差異具有統(tǒng)計學意義(P < 0.05)。結論 消癌平注射液聯(lián)合注射用順鉑治療膀胱癌的有效率較高,可明顯改善患者的生活質量,不良反應少,效果滿意,值得在臨床上進一步推廣和應用。

Objective To explore the clinical effects of Xiaoaiping Injection combined with cisplatin in the treatment of bladder cancer. Methods Patients (100 cases) with bladder cancer of Dongfang Hospital of Beijing University of Chinese Medicine from May 2011 to December 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Cisplatin for injection 6 mg added in 40 mL normal saline, three times per week, and 3 weeks undergoing therapy as one treatment period. The patients in the treatment group were iv administered with Xiaoaiping Injecton on the basis of control group, 2 tubes/time, once daily. One course of treatment was three weeks, and two groups were treated for three courses. After treatment, the efficacy was evaluated, and recent quality of life and drug adverse reactions of two groups were observed. Results After treatment, the total effective rate of treatment groups was 90.0%, which was higher than that (72.0%) of control group, and there were differences between two groups (P < 0.05). The scores of self perceived symptoms, daily life, social activities, psychological and emotional state, physical and physiological function, and total score in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). The incidences of adverse reaction such as white blood cells and platelets reduced, nausea and vomiting, alopecia, anemia, and skin rash were significantly lower than those in the control group, and the difference was statistically significant in the same group (P < 0.05). Conclusion Xiaoaiping Injection combined with Cisplatin for injection in treatment of bladder cancer has higher efficiency, can significantly improve the quality of life of patients, less drug adverse reactions, satisfactory results, which has a certain clinical application value.

北京中醫(yī)藥大學中西醫(yī)結合腫瘤治療協(xié)同創(chuàng)新中心項目(京中字[2013]198號)