目的 探討羥基脲致不良反應(yīng)(ADR)發(fā)生的一般規(guī)律和特點(diǎn),為臨床合理用藥提供參考。方法 檢索中國(guó)期刊全文數(shù)據(jù)庫(CNKI)、萬方數(shù)字化期刊全文庫、中文科技期刊全文數(shù)據(jù)庫(維普)等數(shù)據(jù)庫建庫至2015年9月報(bào)道的羥基脲致ADR的文獻(xiàn),并進(jìn)行分析和討論。結(jié)果 羥基脲引起的不良反應(yīng)共52例,其中男性明顯多于女性,年齡多集中于41～80歲;慢性粒細(xì)胞白血病發(fā)生的ADR例數(shù)最多;有服用當(dāng)天或短時(shí)間內(nèi)就出現(xiàn)的ADR,服用超過3年的患者出現(xiàn)ADR占比最大,為69.23%;羥基脲引發(fā)的ADR以皮膚器官損害為主,其中皮膚潰瘍所占比例最大,為82.69%。結(jié)論 羥基脲引發(fā)的ADR較為常見,臨床使用時(shí)應(yīng)及時(shí)處理,以確?；颊哂盟幇踩?。

Objective To investigate the general regularity and characteristics of adverse drug reaction (ADR) induced by hydroxycarbamide, and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and other databases were retrieved from database foundation to September 2015, and the literature involving cases were analyzed and discussed. Results A total of 52 cases reduced by hydroxycarbamide were analyzed, in which men with ADR induced by hydroxycarbamide were more than women, and the ages of patients were mainly 41 — 80 years old. Patients with chronic granulocytic leukemia had the most ADR cases. There were ADR happened in the same day or within a short time, while the most cases (69.23%) occurred in the medication over three years. ADR induced by hydroxycarbamide mainly were skin system, in which skin ulcer took the most ratios (82.69%). Conclusion ADR induced by hydroxycarbamide is common in clinic. The using of hydroxycarbamide should be treated promptly, to ensure the medication safety.