目的 研究燈盞細(xì)辛注射液聯(lián)合胞磷膽堿鈉膠囊治療腦梗死患者的臨床療效。方法 2012年1月—2015年2月北京市東城區(qū)第一人民醫(yī)院神經(jīng)內(nèi)科收治的腦梗死患者84例,隨機(jī)分為對照組和治療組,每組各42例。對照組在常規(guī)治療的基礎(chǔ)上口服胞磷膽堿鈉膠囊,0.2 g/次,3次/d。治療組在對照組治療基礎(chǔ)上靜脈滴注燈盞細(xì)辛注射液,40 mL加入0.9%生理鹽水250 mL中,1次/d。兩組患者的治療時間均為14 d。觀察兩組的臨床療效,同時比較兩組治療前后超氧化物岐化酶(SOD)、血清超敏C反應(yīng)蛋白(CRP)、神經(jīng)功能缺損程度(NIHSS)評分、Barthel指數(shù)、血漿黏度、全血黏度、纖維蛋白原、血小板聚集率、紅細(xì)胞壓積的變化情況。結(jié)果 治療后,對照組和治療組的總有效率分別為61.90%、83.33%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者CRP、NIHSS評分、血漿黏度、全血黏度、纖維蛋白原、血小板聚集率、紅細(xì)胞壓積均顯著降低,SOD、Barthel指數(shù)均顯著升高,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 燈盞細(xì)辛注射液聯(lián)合胞磷膽堿鈉膠囊治療腦梗死具有較好的臨床療效,有利于患者神經(jīng)功能的恢復(fù),改善生活能力,具有較好的臨床使用價值。

Objective To study the effect of Dengzhanxixin Injection combined with Citicoline Sodium Capsules in treatment of cerebral infarction. Methods Patients (84 cases) with cerebral infarction in Department of Neurology of the First People's Hospital of Beijing Dongcheng District from 2013 January to 2015 February were randomly divided into control and treatment groups, and each group had 42 cases. The patients in the control group were po administered with Citicoline Sodium Capsules on the basis of conventional treatment, 0.2 g/time, three times daily. The patients in the treatment group were iv administered with Dengzhanxixin Injection on the basis of control group, 40 mL added into 0.9% normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacy were evaluated, and the changes of SOD, CRP, NIHSS score, Barthel index, whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate and erythrocyte deposited in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 61.90% and 83.33%, respectively, and there were differences between two groups (P < 0.05). After treatment, CRP, NIHSS score, whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate and erythrocyte deposited were significantly decreased, and SOD and Barthel index were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Dengzhanxixin Injection combined with Citicoline Sodium Capsules has clinical curative effect in treatment of cerebral infarction, benefit to the recovery of neural function, also can improve the living ability of patients, which has a certain clinical application value.