目的 觀察奧美沙坦酯氫氯噻嗪片治療高血壓的臨床療效。方法 選取2013年5月—2015年5月于北京市房山區(qū)良鄉(xiāng)地區(qū)社區(qū)衛(wèi)生服務(wù)中心就診的120例高血壓患者,用隨機(jī)數(shù)表法分為對照組和治療組,每組各60例。對照組口服氯沙坦鉀片,1片/次,1次/d。治療組口服奧美沙坦酯氫氯噻嗪片,1片/次,1次/d。兩組均連續(xù)治療8周。于患者治療前1天和服藥8周后進(jìn)行兩組患者的24 h動態(tài)血壓監(jiān)測,并測定心血管危險因素高敏C反應(yīng)蛋白(hsCRP)、同型半胱氨酸(Hcy)水平。結(jié)果 治療后治療組的總有效率為85.0%,對照組的總有效率為73.3%,兩組總有效率比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后治療組24 h平均收縮壓、24 h平均舒張壓、白晝平均收縮壓、白晝平均舒張壓、夜間平均收縮壓、夜間平均舒張壓、白晝收縮壓變異、白晝舒張壓變異、夜間收縮壓變異、夜間舒張壓變異明顯低于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組hsCRP、Hcy水平顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);且治療組的降低程度優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 奧美沙坦酯氫氯噻嗪片治療高血壓病不僅降壓作用強(qiáng),且血壓變異性小,還能降低心血管危險因素,具有一定的臨床推廣應(yīng)用價值。

Objective To explore clinical efficacy of Olmesartan Medoxomil Hydrochlorothiazide Tablets in treatment of hypertension. Methods Patients (120 cases) with hypertension in Beijing Fangshan District Liangxiang Community Health Service Center from May 2013 to May 2015 were divided into control and treatment groups using a random number table method, and each group had 60 cases. The patients in the control group were po administered with Losartan Potassium Tablets, 1 tablet/time, once daily. The patients in the treatment group were po administered with Olmesartan Medoxomil Hydrochlorothiazide Tablets, 1 tablet/time, once daily. The patients in two groups were treated for 8 weeks. At one day before treatment and 8 weeks after treatment, 24 h ambulatory blood pressure was monitored, and levels of cardiovascular risk factors of high-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) were determined. Results After treatment, the efficacies in the control and treatment groups were 73.3% and 85.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, 24 h average systolic blood pressure, 24 h mean diastolic blood pressure, daytime mean systolic blood pressure, daytime mean diastolic blood pressure, and night mean systolic blood pressure, night mean diastolic blood pressure, and variations of daytime systolic blood pressure, daytime systolic blood pressure, daytime diastolic blood pressure, night systolic blood pressure, and night diastolic blood pressure were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were obviously lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, levels of hsCRP and Hcy in two groups were obviously decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Olmesartan Medoxomil Hydrochlorothiazide Tablets has the good clinical effect in treatment of hypertension, and it has not only strong antihypertensive effect, but also small blood pressure variability, also can reduce the cardiovascular risk factors,, which has a certain clinical application value.