目的 探討清熱散結(jié)膠囊聯(lián)合異維A酸軟膠囊治療中、重度痤瘡的臨床療效。方法 選取2014年10月—2015年6月重慶市紅十字會醫(yī)院(江北區(qū)人民醫(yī)院)皮膚科收治的中、重度痤瘡患者100例,隨機分為對照組和治療組,每組各50例。對照組在常規(guī)治療基礎(chǔ)上口服異維A酸軟膠囊,10 mg/次,2次/d。治療組在對照組治療基礎(chǔ)上口服清熱散結(jié)膠囊5粒/次,3次/d,連用10～14 d,停7～10 d,再重復(fù)。兩組均連續(xù)治療3個月。觀察兩組的臨床療效,同時比較治療前后兩組皮膚病生活質(zhì)量指數(shù)(DLQI)評分的變化情況。結(jié)果 治療后,對照組和治療組的總有效率分別為74.0%、90.0%,兩組總有效率比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后兩組DLQI量表評分均顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);且治療后治療組DLQI評分顯著低于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 清熱散結(jié)膠囊聯(lián)合異維A酸軟膠囊治療中、重度痤瘡療效顯著,可顯著提高患者的生活質(zhì)量,且不良反應(yīng)發(fā)生率較低,具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the curative effect of Qingre Sanjie Capsules combined with Isotretinoin Soft Capsules in treatment of medium and severe acne. Methods Patients (100 cases) with medium and severe acne in Department of Dermatology of Chongqing Red Cross Hospital (People's Hospital of Jiangbei District) from October 2014 to June 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Isotretinoin Soft Capsules on the basis of conventional treatment, 10 mg/time, twice daily. The patients in the treatment group were po administered with Qingre Sanjie Capsules on the basis of control group, 5 grains/time, three times daily, for 10—14 d, then stopped for 7—10 d, and repeated. The patients in two groups were treated for 3 monthes. After treatment, the clinical efficacy was evaluated, and the changes of dermatology life quality index (DLQI) in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, DLQI in two groups was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the DLQI in treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Qingre Sanjie Capsules combined with Isotretinoin Soft Capsules has clinical curative effect in treatment of medium and severe acne, and can significantly improve the life quality of patients with lower incidence of adverse reactions, which has a certain clinical application value.