目的 了解武漢大學(xué)人民醫(yī)院抗癲癇藥物的使用情況,為醫(yī)護(hù)人員提供參考。方法 選取武漢大學(xué)人民醫(yī)院2013年7月—2015年8月151份癥狀性癲癇病歷進(jìn)行回顧性分析,對(duì)患者的性別及年齡、病因、用藥方案、抗癲癇藥物的使用情況以及不良反應(yīng)進(jìn)行分類(lèi)統(tǒng)計(jì)。結(jié)果 151例癥狀性癲癇患者中,男性多于女性;年齡多集中在51～64歲的患者;病因復(fù)雜,多集中在腦血管疾病、腦外傷、顱內(nèi)感染3大原因;癲癇形式主要為全身性發(fā)作的強(qiáng)直陣攣性發(fā)作,抗癲癇治療方案多采用單一用藥的形式,而且丙戊酸鈉和奧卡西平是臨床上最常用的抗癲癇藥物。結(jié)論 從藥物流行病學(xué)角度考察了武漢大學(xué)人民醫(yī)院神經(jīng)內(nèi)科抗癲癇藥物的藥物利用模式,對(duì)臨床制定抗癲癇治療方案具有積極的意義。

Objective To realize the utilizatin of of antiepileptic drugs in Department of Neurology in Renmin Hospital of Wuhan University, in order to provide a reference for medical staff. Methods Records of 151 patients with symptomatic epilepsy in Renmin Hospital of Wuhan University from July 2013 to August 2015 were extracted. Gender, age, etiology, and drug programs of patients, utilization of antiepileptic drugs, and adverse reactions were classified statistically. Results In patients (151 cases) with symptomatic epilepsy, men were more than women, and more were focused on 51 — 64 years old. Etiology was complex, and more were focused on cerebrovascular diseases, brain trauma, and intracranial infection. Generalized tonic-clonic seizure was the main form of epilepsy. A single drug was mostly used as drug programs for patients with symptomatic epilepsy. And sodium valproate and oxcarbazepine were the most common used drugs in the clinical practice. Conclusion The drug utilization pattern of antiepileptic drugs in Department of Neurology in Renmin Hospital of Wuhan University is discussed in the view of drug epidemiology, and it will have positive meaning for clinic to make antiepileptic medications.