目的 分析天津市腫瘤醫(yī)院抗菌藥物的使用情況,為促進(jìn)臨床合理用藥提供依據(jù)。方法 調(diào)取2010—2014年天津市腫瘤醫(yī)院抗菌藥物的相關(guān)信息,對品規(guī)、銷售金額、用藥頻度(DDDs)、日均費(fèi)用(DDC)及藥品排序比(B/A)進(jìn)行統(tǒng)計分析。結(jié)果 2010—2014年,抗菌藥物的品規(guī)數(shù)顯著減少,銷售金額2010—2012年先下降,然后呈現(xiàn)上升的趨勢,頭孢菌素類、碳青霉烯類與抗真菌藥物的DDDs逐年上升,以碳青霉烯類增速最快。DDDs排名前10位的抗菌藥物中,絕大多數(shù)藥物的DDC超過100。絕大多數(shù)抗菌藥物的B/A基本接近于1,表明大多數(shù)藥物同步性較好。結(jié)論 天津市腫瘤醫(yī)院抗菌藥物的使用日趨合理,但碳青霉烯類藥物的使用率日漸增高,應(yīng)加強(qiáng)監(jiān)督管理。

Objective To analyze the utilization of antimicrobial drugs in Tianjin Cancer Hospital, and to provide reference for rational use of drugs in clinic. Methods The utilization information of antimicrobial drugs in Tianjin Cancer Hospital from 2010 to 2014 was extracted, and the variety and specification numbers, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed statistically. Results The variety and specification numbers of antibacterial drugs were decreased from 2010 to 2014. The consumption sum decreased from 2010 to 2012, and increased from then on. DDDs of cephalosporins, carbapenems and antifungal agents increased year by year, and carbapenems increased most rapidly. DDC of most drugs exceed 100 in antimicrobial drugs with top 10 DDDs. B/A of most antimicrobial drugs closed to 1.00, indicating that the synchronism was better. Conclusion The use of antimicrobial drugs is becoming more rational in Tianjin Cancer Hospital. However, the use of carbapenems increase rapidly, which needs further efforts to strengthen the management.